Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis

Background and Objective: This study was done to determine the role of brain histaminergic system on the tail pinch-induced behavioral responses. Methods: In male Albino Wistar rats (250-300 gr), microdialysis probes were implanted in the lateral ventricles under chloral hydrate anesthesia. (400 mg/...

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Autores principales:	A Vahab Zadeh, E Abbasi, M Khorasani
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	stress antihistanmine histaminergic Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/42954ccce1a64765afade2c4b8233f1a
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spelling	oai:doaj.org-article:42954ccce1a64765afade2c4b8233f1a2021-11-10T09:19:48ZRole of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis1561-41072251-7170https://doaj.org/article/42954ccce1a64765afade2c4b8233f1a2002-10-01T00:00:00Zhttp://jbums.org/article-1-2805-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: This study was done to determine the role of brain histaminergic system on the tail pinch-induced behavioral responses. Methods: In male Albino Wistar rats (250-300 gr), microdialysis probes were implanted in the lateral ventricles under chloral hydrate anesthesia. (400 mg/kg i.p) by stereotaxy method. Rats were examined after recovery while Ringer solution (Ca++=2mM) perfused in implanted probes. Five min tail pinch was applied for control group. In sham group, Ringer solution was perfused via microdialysis probes while 5 tail pinch stress was performed. In both test groups, histamine (10µM) and promethazine (10µM) were added to the Ringer solution. Duration of these behavioral responses was recorded and sham and test group were compared with control and sham group, respectively. Variations were calculated depending on percentage and statistical analysis was done depending on absolute data. Student paired t-test and ANOVA were used for comparing within the same and different groups, respectively. Findings: According to the results, histamine increases duration of tail pinch induced behavioral response by 38±8% and promethazine as an antihistamine decreases it by 43±13%. Conclusion: The results showed that brain histaminergic system has a stimulating role on tail-pinch induced behavioral responses.A Vahab ZadehE AbbasiM KhorasaniBabol University of Medical SciencesarticlestressantihistanminehistaminergicMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 4, Pp 7-12 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	stress antihistanmine histaminergic Medicine R Medicine (General) R5-920
spellingShingle	stress antihistanmine histaminergic Medicine R Medicine (General) R5-920 A Vahab Zadeh E Abbasi M Khorasani Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
description	Background and Objective: This study was done to determine the role of brain histaminergic system on the tail pinch-induced behavioral responses. Methods: In male Albino Wistar rats (250-300 gr), microdialysis probes were implanted in the lateral ventricles under chloral hydrate anesthesia. (400 mg/kg i.p) by stereotaxy method. Rats were examined after recovery while Ringer solution (Ca++=2mM) perfused in implanted probes. Five min tail pinch was applied for control group. In sham group, Ringer solution was perfused via microdialysis probes while 5 tail pinch stress was performed. In both test groups, histamine (10µM) and promethazine (10µM) were added to the Ringer solution. Duration of these behavioral responses was recorded and sham and test group were compared with control and sham group, respectively. Variations were calculated depending on percentage and statistical analysis was done depending on absolute data. Student paired t-test and ANOVA were used for comparing within the same and different groups, respectively. Findings: According to the results, histamine increases duration of tail pinch induced behavioral response by 38±8% and promethazine as an antihistamine decreases it by 43±13%. Conclusion: The results showed that brain histaminergic system has a stimulating role on tail-pinch induced behavioral responses.
format	article
author	A Vahab Zadeh E Abbasi M Khorasani
author_facet	A Vahab Zadeh E Abbasi M Khorasani
author_sort	A Vahab Zadeh
title	Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
title_short	Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
title_full	Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
title_fullStr	Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
title_full_unstemmed	Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
title_sort	role of brain histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/42954ccce1a64765afade2c4b8233f1a
work_keys_str_mv	AT avahabzadeh roleofbrainhistaminergicsystemonthetailpinchinducedbehavioralresponsesusingbrainmicrodialysis AT eabbasi roleofbrainhistaminergicsystemonthetailpinchinducedbehavioralresponsesusingbrainmicrodialysis AT mkhorasani roleofbrainhistaminergicsystemonthetailpinchinducedbehavioralresponsesusingbrainmicrodialysis
_version_	1718440095498895360

Role of brain Histaminergic system on the tail pinch-induced behavioral responses using brain microdialysis

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