Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering

Electrospinning is an innovative new fibre technology that aims to design and fabricate membranes suitable for a wide range of tissue engineering (TE) applications including vascular grafts, which is the main objective of this research work. This study dealt with fabricating and characterising bilay...

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Autores principales:	Morteza Bazgir, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, Farshid Sefat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	electrospinning coaxial bilayer polycaprolactone (PCL) poly lactic-co-glycolic acid (PLGA) contact angle Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
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spelling	oai:doaj.org-article:429aa83630584c8ea269b0c20168a6822021-11-11T17:52:06ZFabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering10.3390/ma142162951996-1944https://doaj.org/article/429aa83630584c8ea269b0c20168a6822021-10-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6295https://doaj.org/toc/1996-1944Electrospinning is an innovative new fibre technology that aims to design and fabricate membranes suitable for a wide range of tissue engineering (TE) applications including vascular grafts, which is the main objective of this research work. This study dealt with fabricating and characterising bilayer structures comprised of an electrospun sheet made of polycaprolactone (PCL, inner layer) and an outer layer made of poly lactic-co-glycolic acid (PLGA) and a coaxial porous scaffold with a micrometre fibre structure was successfully produced. The membranes’ propriety for intended biomedical applications was assessed by evaluating their morphological structure/physical properties and structural integrity when they underwent the degradation process. A scanning electron microscope (SEM) was used to assess changes in the electrospun scaffolds’ structural morphology such as in their fibre diameter, pore size (μm) and the porosity of the scaffold surface which was measured with Image J software. During the 12-week degradation process at room temperature, most of the scaffolds showed a similar trend in their degradation rate except the 60 min scaffolds. The coaxial scaffold had significantly less mass loss than the bilayer PCL/PLGA scaffold with 1.348% and 18.3%, respectively. The mechanical properties of the fibrous membranes were measured and the coaxial scaffolds showed greater tensile strength and elongation at break (%) compared to the bilayer scaffolds. According to the results obtained in this study, it can be concluded that a scaffold made with a coaxial needle is more suitable for tissue engineering applications due to the improved quality and functionality of the resulting polymeric membrane compared to the basic electrospinning process. However, whilst fabricating a vascular graft is the main aim of this research work, the biological data will not present in this paper.Morteza BazgirWei ZhangXimu ZhangJacobo EliesMorvarid SaeinasabPhil CoatesMansour YouseffiFarshid SefatMDPI AGarticleelectrospinningcoaxialbilayerpolycaprolactone (PCL)poly lactic-co-glycolic acid (PLGA)contact angleTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6295, p 6295 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrospinning coaxial bilayer polycaprolactone (PCL) poly lactic-co-glycolic acid (PLGA) contact angle Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	electrospinning coaxial bilayer polycaprolactone (PCL) poly lactic-co-glycolic acid (PLGA) contact angle Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Morteza Bazgir Wei Zhang Ximu Zhang Jacobo Elies Morvarid Saeinasab Phil Coates Mansour Youseffi Farshid Sefat Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
description	Electrospinning is an innovative new fibre technology that aims to design and fabricate membranes suitable for a wide range of tissue engineering (TE) applications including vascular grafts, which is the main objective of this research work. This study dealt with fabricating and characterising bilayer structures comprised of an electrospun sheet made of polycaprolactone (PCL, inner layer) and an outer layer made of poly lactic-co-glycolic acid (PLGA) and a coaxial porous scaffold with a micrometre fibre structure was successfully produced. The membranes’ propriety for intended biomedical applications was assessed by evaluating their morphological structure/physical properties and structural integrity when they underwent the degradation process. A scanning electron microscope (SEM) was used to assess changes in the electrospun scaffolds’ structural morphology such as in their fibre diameter, pore size (μm) and the porosity of the scaffold surface which was measured with Image J software. During the 12-week degradation process at room temperature, most of the scaffolds showed a similar trend in their degradation rate except the 60 min scaffolds. The coaxial scaffold had significantly less mass loss than the bilayer PCL/PLGA scaffold with 1.348% and 18.3%, respectively. The mechanical properties of the fibrous membranes were measured and the coaxial scaffolds showed greater tensile strength and elongation at break (%) compared to the bilayer scaffolds. According to the results obtained in this study, it can be concluded that a scaffold made with a coaxial needle is more suitable for tissue engineering applications due to the improved quality and functionality of the resulting polymeric membrane compared to the basic electrospinning process. However, whilst fabricating a vascular graft is the main aim of this research work, the biological data will not present in this paper.
format	article
author	Morteza Bazgir Wei Zhang Ximu Zhang Jacobo Elies Morvarid Saeinasab Phil Coates Mansour Youseffi Farshid Sefat
author_facet	Morteza Bazgir Wei Zhang Ximu Zhang Jacobo Elies Morvarid Saeinasab Phil Coates Mansour Youseffi Farshid Sefat
author_sort	Morteza Bazgir
title	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
title_short	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
title_full	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
title_fullStr	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
title_full_unstemmed	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering
title_sort	fabrication and characterization of pcl/plga coaxial and bilayer fibrous scaffolds for tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/429aa83630584c8ea269b0c20168a682
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_version_	1718431997515268096

Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering

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