Targeting PINK1 Using Natural Products for the Treatment of Human Diseases

PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondri...

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Autores principales:	Yan-Qin Li, Fan Zhang, Li-Ping Yu, Jian-Kang Mu, Ya-Qin Yang, Jie Yu, Xing-Xin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/429b517e58164366bd03052be1efee27
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spelling	oai:doaj.org-article:429b517e58164366bd03052be1efee272021-11-08T02:37:19ZTargeting PINK1 Using Natural Products for the Treatment of Human Diseases2314-614110.1155/2021/4045819https://doaj.org/article/429b517e58164366bd03052be1efee272021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4045819https://doaj.org/toc/2314-6141PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondrial-associated disorders. Many natural products could regulate PINK1 to relieve PINK1-associated diseases. Here, we review the structure and function of PINK1, its relationship to human diseases, and the regulation of natural products to PINK1. We further highlight that the discovery of natural PINK1 regulators represents an attractive strategy for the treatment of PINK1-related diseases, including liver and heart diseases, cancer, and Parkinson’s disease. Moreover, investigating PINK1 regulation of natural products can enhance the in-depth comprehension of the mechanism of action of natural products.Yan-Qin LiFan ZhangLi-Ping YuJian-Kang MuYa-Qin YangJie YuXing-Xin YangHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yan-Qin Li Fan Zhang Li-Ping Yu Jian-Kang Mu Ya-Qin Yang Jie Yu Xing-Xin Yang Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
description	PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondrial-associated disorders. Many natural products could regulate PINK1 to relieve PINK1-associated diseases. Here, we review the structure and function of PINK1, its relationship to human diseases, and the regulation of natural products to PINK1. We further highlight that the discovery of natural PINK1 regulators represents an attractive strategy for the treatment of PINK1-related diseases, including liver and heart diseases, cancer, and Parkinson’s disease. Moreover, investigating PINK1 regulation of natural products can enhance the in-depth comprehension of the mechanism of action of natural products.
format	article
author	Yan-Qin Li Fan Zhang Li-Ping Yu Jian-Kang Mu Ya-Qin Yang Jie Yu Xing-Xin Yang
author_facet	Yan-Qin Li Fan Zhang Li-Ping Yu Jian-Kang Mu Ya-Qin Yang Jie Yu Xing-Xin Yang
author_sort	Yan-Qin Li
title	Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
title_short	Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
title_full	Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
title_fullStr	Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
title_full_unstemmed	Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
title_sort	targeting pink1 using natural products for the treatment of human diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/429b517e58164366bd03052be1efee27
work_keys_str_mv	AT yanqinli targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT fanzhang targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT lipingyu targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT jiankangmu targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT yaqinyang targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT jieyu targetingpink1usingnaturalproductsforthetreatmentofhumandiseases AT xingxinyang targetingpink1usingnaturalproductsforthetreatmentofhumandiseases
_version_	1718442993435803648

Targeting PINK1 Using Natural Products for the Treatment of Human Diseases

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