Etiology of sinonasal inverted papilloma: A narrative review

Objective: Sinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversi...

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Autores principales:	Ming-Jie Wang, Julia E. Noel
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/429bac4720e9476593c631c8cb97d7f7
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spelling	oai:doaj.org-article:429bac4720e9476593c631c8cb97d7f72021-12-02T14:14:17ZEtiology of sinonasal inverted papilloma: A narrative review2095-881110.1016/j.wjorl.2016.11.004https://doaj.org/article/429bac4720e9476593c631c8cb97d7f72017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300713https://doaj.org/toc/2095-8811Objective: Sinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial. Methods: Computerized searches were performed in PubMed, Scopus, and Google scholar through May 2015. In this review, etiologic factors including human papilloma virus (HPV), EpsteinâBarr virus (EBV), cell cycle related proteins and angiogenic factors, occupational and environmental exposures, and chronic inflammation, will be discussed. Results: Many studies indicate that HPV has been detected in a significant percentage of IP, while EBV has not been shown to be significantly associated. Certain cell cycle regulatory factors and angiogenic proteins contribute to the dysregulation of proliferation and apoptosis, and facilitate migration and tumor invasion. Occupational exposures, such as welding and organic solvents, have been implicated, and smoking seems more critical to recurrence and dysplasia rather than initial IP occurrence. Chronic inflammation may also have a causative relationship with inverted papilloma, but the mechanism is unclear. Conclusions: Though etiology of sinonasal IP remains controversial, the studies reviewed here indicate a role for viral infection, cell cycle and angiogenic factors, environmental and occupational exposure, and chronic inflammation. Further study on etiologic factors is necessary for clinical guidance and therapeutic targets. Keywords: Sinonasal inverted papilloma, Human papilloma virus, Occupational exposure, Smoking, Chronic inflammationMing-Jie WangJulia E. NoelKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 3, Iss 1, Pp 54-58 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Ming-Jie Wang Julia E. Noel Etiology of sinonasal inverted papilloma: A narrative review
description	Objective: Sinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial. Methods: Computerized searches were performed in PubMed, Scopus, and Google scholar through May 2015. In this review, etiologic factors including human papilloma virus (HPV), EpsteinâBarr virus (EBV), cell cycle related proteins and angiogenic factors, occupational and environmental exposures, and chronic inflammation, will be discussed. Results: Many studies indicate that HPV has been detected in a significant percentage of IP, while EBV has not been shown to be significantly associated. Certain cell cycle regulatory factors and angiogenic proteins contribute to the dysregulation of proliferation and apoptosis, and facilitate migration and tumor invasion. Occupational exposures, such as welding and organic solvents, have been implicated, and smoking seems more critical to recurrence and dysplasia rather than initial IP occurrence. Chronic inflammation may also have a causative relationship with inverted papilloma, but the mechanism is unclear. Conclusions: Though etiology of sinonasal IP remains controversial, the studies reviewed here indicate a role for viral infection, cell cycle and angiogenic factors, environmental and occupational exposure, and chronic inflammation. Further study on etiologic factors is necessary for clinical guidance and therapeutic targets. Keywords: Sinonasal inverted papilloma, Human papilloma virus, Occupational exposure, Smoking, Chronic inflammation
format	article
author	Ming-Jie Wang Julia E. Noel
author_facet	Ming-Jie Wang Julia E. Noel
author_sort	Ming-Jie Wang
title	Etiology of sinonasal inverted papilloma: A narrative review
title_short	Etiology of sinonasal inverted papilloma: A narrative review
title_full	Etiology of sinonasal inverted papilloma: A narrative review
title_fullStr	Etiology of sinonasal inverted papilloma: A narrative review
title_full_unstemmed	Etiology of sinonasal inverted papilloma: A narrative review
title_sort	etiology of sinonasal inverted papilloma: a narrative review
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/429bac4720e9476593c631c8cb97d7f7
work_keys_str_mv	AT mingjiewang etiologyofsinonasalinvertedpapillomaanarrativereview AT juliaenoel etiologyofsinonasalinvertedpapillomaanarrativereview
_version_	1718391721673359360

Etiology of sinonasal inverted papilloma: A narrative review

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