Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma

Hsin-Yu Yang,1 Yu-Fan Chang,1,2 Chih-Chien Hsu,1,2 Yu-Chieh Ko,1–3 Catherine Jui-Ling Liu,1,3 Mei-Ju Chen1,3 1Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; 2Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; 3School of Medicine,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang HY, Chang YF, Hsu CC, Ko YC, Liu CJL, Chen MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	macular ganglion cell paracentral scotoma glaucoma optical coherence tomography Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/429cc84614274dd5a4219c10f5629e59
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:429cc84614274dd5a4219c10f5629e59
record_format	dspace
spelling	oai:doaj.org-article:429cc84614274dd5a4219c10f5629e592021-12-02T08:39:07ZMacular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma1177-5483https://doaj.org/article/429cc84614274dd5a4219c10f5629e592018-11-01T00:00:00Zhttps://www.dovepress.com/macular-ganglion-cell-asymmetry-for-detecting-paracentral-scotoma-in-e-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hsin-Yu Yang,1 Yu-Fan Chang,1,2 Chih-Chien Hsu,1,2 Yu-Chieh Ko,1–3 Catherine Jui-Ling Liu,1,3 Mei-Ju Chen1,3 1Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; 2Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; 3School of Medicine, National Yang-Ming University, Taipei, Taiwan Purpose: We evaluated macular ganglion cell asymmetry as a tool for diagnosing paracentral scotoma (PCS) in early glaucoma.Patients and methods: This prospective study compared 58 patients with early glaucoma and PCS to 58 age-matched control individuals. All glaucomatous eyes had scotoma within the central 12 degrees of fixation and confined to one hemifield. We measured circumpapillary retinal nerve fiber layer (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness, and optic nerve head (ONH) parameters with Cirrus spectral domain optical coherence tomography. Macular ganglion cell asymmetry was expressed as the absolute differences and the ratios between the inferior and superior hemispheres, inferotemporal (IT) and superotemporal (ST) areas, IT and superonasal (SN) areas, IT and inferonasal (IN) areas, and ST and IN areas. The asymmetry index was the absolute log10 of the ratio. The area under the receiver operating characteristics curve (AUROC) and partial AUROC (pAUROC, specificities ≥90%) were analyzed for each parameter.Results: All GCIPL parameters and most cpRNFL parameters were significantly lower in early glaucoma than in controls. The best discriminating parameters were inferior RNFL thickness, average RNFL thickness, and minimum GCIPL thickness. The macular ganglion cell asymmetry parameters with the largest AUROCs were the log IT/ST index, the absolute difference in IT-ST GCIPL thicknesses, and the log IT/SN index. Performance was comparable between the log IT/ST index and the cpRNFL (inferior RNFL thickness, P=0.129), GCIPL (minimum GCIPL thickness, P=0.358), and ONH parameters (vertical cup-to-disc ratio, P=0.475).Conclusion: The IT/ST asymmetry index may be useful as a new parameter for detecting structural changes in glaucoma patients with PCS.Keywords: macular ganglion cell, paracentral scotoma, glaucoma, optical coherence tomographyYang HYChang YFHsu CCKo YCLiu CJLChen MJDove Medical Pressarticlemacular ganglion cellparacentral scotomaglaucomaoptical coherence tomographyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2253-2260 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	macular ganglion cell paracentral scotoma glaucoma optical coherence tomography Ophthalmology RE1-994
spellingShingle	macular ganglion cell paracentral scotoma glaucoma optical coherence tomography Ophthalmology RE1-994 Yang HY Chang YF Hsu CC Ko YC Liu CJL Chen MJ Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
description	Hsin-Yu Yang,1 Yu-Fan Chang,1,2 Chih-Chien Hsu,1,2 Yu-Chieh Ko,1–3 Catherine Jui-Ling Liu,1,3 Mei-Ju Chen1,3 1Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; 2Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; 3School of Medicine, National Yang-Ming University, Taipei, Taiwan Purpose: We evaluated macular ganglion cell asymmetry as a tool for diagnosing paracentral scotoma (PCS) in early glaucoma.Patients and methods: This prospective study compared 58 patients with early glaucoma and PCS to 58 age-matched control individuals. All glaucomatous eyes had scotoma within the central 12 degrees of fixation and confined to one hemifield. We measured circumpapillary retinal nerve fiber layer (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness, and optic nerve head (ONH) parameters with Cirrus spectral domain optical coherence tomography. Macular ganglion cell asymmetry was expressed as the absolute differences and the ratios between the inferior and superior hemispheres, inferotemporal (IT) and superotemporal (ST) areas, IT and superonasal (SN) areas, IT and inferonasal (IN) areas, and ST and IN areas. The asymmetry index was the absolute log10 of the ratio. The area under the receiver operating characteristics curve (AUROC) and partial AUROC (pAUROC, specificities ≥90%) were analyzed for each parameter.Results: All GCIPL parameters and most cpRNFL parameters were significantly lower in early glaucoma than in controls. The best discriminating parameters were inferior RNFL thickness, average RNFL thickness, and minimum GCIPL thickness. The macular ganglion cell asymmetry parameters with the largest AUROCs were the log IT/ST index, the absolute difference in IT-ST GCIPL thicknesses, and the log IT/SN index. Performance was comparable between the log IT/ST index and the cpRNFL (inferior RNFL thickness, P=0.129), GCIPL (minimum GCIPL thickness, P=0.358), and ONH parameters (vertical cup-to-disc ratio, P=0.475).Conclusion: The IT/ST asymmetry index may be useful as a new parameter for detecting structural changes in glaucoma patients with PCS.Keywords: macular ganglion cell, paracentral scotoma, glaucoma, optical coherence tomography
format	article
author	Yang HY Chang YF Hsu CC Ko YC Liu CJL Chen MJ
author_facet	Yang HY Chang YF Hsu CC Ko YC Liu CJL Chen MJ
author_sort	Yang HY
title	Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
title_short	Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
title_full	Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
title_fullStr	Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
title_full_unstemmed	Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
title_sort	macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/429cc84614274dd5a4219c10f5629e59
work_keys_str_mv	AT yanghy macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma AT changyf macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma AT hsucc macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma AT koyc macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma AT liucjl macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma AT chenmj macularganglioncellasymmetryfordetectingparacentralscotomainearlyglaucoma
_version_	1718398413113917440

Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma

Ejemplares similares