Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect against bacterial infection, but it does so via pyr...

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Autores principales:	Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang, Wenting Xu, Jinchao Tan, Tianjian Hu, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42a1a7d861bb4e0ab316b0466d23784b
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spelling	oai:doaj.org-article:42a1a7d861bb4e0ab316b0466d23784b2021-12-02T14:41:16ZSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish10.1038/s41467-018-04984-12041-1723https://doaj.org/article/42a1a7d861bb4e0ab316b0466d23784b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04984-1https://doaj.org/toc/2041-1723In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect against bacterial infection, but it does so via pyrin death domain interactions.Dahai YangXin ZhengShouwen ChenZhuang WangWenting XuJinchao TanTianjian HuMingyu HouWenhui WangZhaoyan GuQiyao WangRuilin ZhangYuanxing ZhangQin LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dahai Yang Xin Zheng Shouwen Chen Zhuang Wang Wenting Xu Jinchao Tan Tianjian Hu Mingyu Hou Wenhui Wang Zhaoyan Gu Qiyao Wang Ruilin Zhang Yuanxing Zhang Qin Liu Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
description	In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect against bacterial infection, but it does so via pyrin death domain interactions.
format	article
author	Dahai Yang Xin Zheng Shouwen Chen Zhuang Wang Wenting Xu Jinchao Tan Tianjian Hu Mingyu Hou Wenhui Wang Zhaoyan Gu Qiyao Wang Ruilin Zhang Yuanxing Zhang Qin Liu
author_facet	Dahai Yang Xin Zheng Shouwen Chen Zhuang Wang Wenting Xu Jinchao Tan Tianjian Hu Mingyu Hou Wenhui Wang Zhaoyan Gu Qiyao Wang Ruilin Zhang Yuanxing Zhang Qin Liu
author_sort	Dahai Yang
title	Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
title_short	Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
title_full	Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
title_fullStr	Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
title_full_unstemmed	Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
title_sort	sensing of cytosolic lps through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/42a1a7d861bb4e0ab316b0466d23784b
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Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

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