Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics

Traditional chemical methods for nitro reduction are typically conducted under harsh conditions and are readily explosive, such as hydrogen pressurization and zinc powder reduction. Nitroreductase (NTR) as a biocatalyst may represent a promising strategy to solve this synthetic challenging. Unfortun...

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Autores principales:	Baoxing Shen, Rui Ding, Jianan Dai, Yuan Ji, Qingzhuo Wang, Yuwen Wang, He Huang, Xing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co. Ltd. 2021
Materias:	Biocatalyst Metal-organic framework Nitroreductase NTR@ZIF-8 Nitro-aromatics Chemical technology TP1-1185 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/42a1eb29be96493e9402b9ea7486e4ac
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spelling	oai:doaj.org-article:42a1eb29be96493e9402b9ea7486e4ac2021-12-02T05:03:57ZEncapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics2666-554910.1016/j.gresc.2021.09.001https://doaj.org/article/42a1eb29be96493e9402b9ea7486e4ac2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266655492100079Xhttps://doaj.org/toc/2666-5549Traditional chemical methods for nitro reduction are typically conducted under harsh conditions and are readily explosive, such as hydrogen pressurization and zinc powder reduction. Nitroreductase (NTR) as a biocatalyst may represent a promising strategy to solve this synthetic challenging. Unfortunately, due to the availability of this enzyme, the lack of long-term stability as well as challenging recovery process, very limited work was reported about its applicability for the reduction of nitro groups. Here, based on the highly efficient expression of NTR in our lab, we firstly reported the encapsulation of NTR into ZIF-8 to form NTR@ZIF-8. The resulting framework composite demonstrated an excellent protective capability of enzyme against harsh environment and could also simplify the complex downstream separation and recovery operations. Moreover, after five successive cycles of reuse to reduce 4-NP, the residual NTR@ZIF-8 still reserved a certain activity, which can significantly reduce the processing cost and might be applicable in the industries in the future.Baoxing ShenRui DingJianan DaiYuan JiQingzhuo WangYuwen WangHe HuangXing ZhangKeAi Communications Co. Ltd.articleBiocatalystMetal-organic frameworkNitroreductaseNTR@ZIF-8Nitro-aromaticsChemical technologyTP1-1185BiochemistryQD415-436ENGreen Synthesis and Catalysis, Vol 2, Iss 4, Pp 367-373 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biocatalyst Metal-organic framework Nitroreductase NTR@ZIF-8 Nitro-aromatics Chemical technology TP1-1185 Biochemistry QD415-436
spellingShingle	Biocatalyst Metal-organic framework Nitroreductase NTR@ZIF-8 Nitro-aromatics Chemical technology TP1-1185 Biochemistry QD415-436 Baoxing Shen Rui Ding Jianan Dai Yuan Ji Qingzhuo Wang Yuwen Wang He Huang Xing Zhang Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
description	Traditional chemical methods for nitro reduction are typically conducted under harsh conditions and are readily explosive, such as hydrogen pressurization and zinc powder reduction. Nitroreductase (NTR) as a biocatalyst may represent a promising strategy to solve this synthetic challenging. Unfortunately, due to the availability of this enzyme, the lack of long-term stability as well as challenging recovery process, very limited work was reported about its applicability for the reduction of nitro groups. Here, based on the highly efficient expression of NTR in our lab, we firstly reported the encapsulation of NTR into ZIF-8 to form NTR@ZIF-8. The resulting framework composite demonstrated an excellent protective capability of enzyme against harsh environment and could also simplify the complex downstream separation and recovery operations. Moreover, after five successive cycles of reuse to reduce 4-NP, the residual NTR@ZIF-8 still reserved a certain activity, which can significantly reduce the processing cost and might be applicable in the industries in the future.
format	article
author	Baoxing Shen Rui Ding Jianan Dai Yuan Ji Qingzhuo Wang Yuwen Wang He Huang Xing Zhang
author_facet	Baoxing Shen Rui Ding Jianan Dai Yuan Ji Qingzhuo Wang Yuwen Wang He Huang Xing Zhang
author_sort	Baoxing Shen
title	Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
title_short	Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
title_full	Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
title_fullStr	Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
title_full_unstemmed	Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
title_sort	encapsulating nitroreductase into metal-organic framework: boosting industrial performance for the reduction of nitro-aromatics
publisher	KeAi Communications Co. Ltd.
publishDate	2021
url	https://doaj.org/article/42a1eb29be96493e9402b9ea7486e4ac
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Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics

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