Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulating both innate and adaptive immune responses again...

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Autores principales:	Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaëlle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M. Jones, Bernard Malissen, Laura K. Mackay, Aziz Moqrich, Francis R. Carbone, Sophie Ugolini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42a3ec0604df491d8f51a1b9be9121c7
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spelling	oai:doaj.org-article:42a3ec0604df491d8f51a1b9be9121c72021-12-02T14:58:51ZNociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection10.1038/s41467-021-22841-62041-1723https://doaj.org/article/42a3ec0604df491d8f51a1b9be9121c72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22841-6https://doaj.org/toc/2041-1723Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulating both innate and adaptive immune responses against HSV-1, thereby offering a potential target for therapy.Jessica FiltjensAnais RogerLinda QuatriniElisabeth WieduwildJordi GouillyGuillaume HoeffelRafaëlle RossignolClara DaherGuilhaume DebroasSandrine HenriClaerwen M. JonesBernard MalissenLaura K. MackayAziz MoqrichFrancis R. CarboneSophie UgoliniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica Filtjens Anais Roger Linda Quatrini Elisabeth Wieduwild Jordi Gouilly Guillaume Hoeffel Rafaëlle Rossignol Clara Daher Guilhaume Debroas Sandrine Henri Claerwen M. Jones Bernard Malissen Laura K. Mackay Aziz Moqrich Francis R. Carbone Sophie Ugolini Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
description	Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulating both innate and adaptive immune responses against HSV-1, thereby offering a potential target for therapy.
format	article
author	Jessica Filtjens Anais Roger Linda Quatrini Elisabeth Wieduwild Jordi Gouilly Guillaume Hoeffel Rafaëlle Rossignol Clara Daher Guilhaume Debroas Sandrine Henri Claerwen M. Jones Bernard Malissen Laura K. Mackay Aziz Moqrich Francis R. Carbone Sophie Ugolini
author_facet	Jessica Filtjens Anais Roger Linda Quatrini Elisabeth Wieduwild Jordi Gouilly Guillaume Hoeffel Rafaëlle Rossignol Clara Daher Guilhaume Debroas Sandrine Henri Claerwen M. Jones Bernard Malissen Laura K. Mackay Aziz Moqrich Francis R. Carbone Sophie Ugolini
author_sort	Jessica Filtjens
title	Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
title_short	Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
title_full	Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
title_fullStr	Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
title_full_unstemmed	Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
title_sort	nociceptive sensory neurons promote cd8 t cell responses to hsv-1 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42a3ec0604df491d8f51a1b9be9121c7
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Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

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