Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial

Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Sporadic reports on the us...

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Autores principales:	Nasrin Saki, Raya Mokhtari, Farnoosh Nozari
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	keloid verapamil triamcinolone Vancouver Scar Scale scar Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/42aaaac573db42aa9eaa64d41a8836c3
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spelling	oai:doaj.org-article:42aaaac573db42aa9eaa64d41a8836c32021-11-17T08:29:50ZComparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial10.5826/dpc.0901a022160-9381https://doaj.org/article/42aaaac573db42aa9eaa64d41a8836c32019-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/517https://doaj.org/toc/2160-9381 Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Sporadic reports on the use of intralesional verapamil suggest its efficacy. Aim: Since there is not sufficient evidence to support the role of intralesional verapamil as an effective alternative modality, it was decided to undertake a randomized study to determine its efficacy as a treatment for keloids. Methods: A randomized, single-blind, single-group comparison with 15 patients (30 scars) was carried out to compare the effects of intralesional triamcinolone with verapamil injections. Injections were scheduled every 3 weeks accompanied by cryotherapy until complete flattening of the scar or maximum 8 sessions, whichever came earlier. Scar evaluation at each stage was done by serial photographic records as well as by Vancouver scar scale. Statistical analysis was done by Wilcoxon and Mann-Whitney U tests using SPSS version 19. Results: In both study groups there was a reduction in height and pliability at the end of the study. Better improvement in height and pliability was seen with triamcinolone in comparison with verapamil. However, a desired change in vascularity and pigmentation was not seen with either of the drugs. Conclusion: Verapamilis not as effective as triamcinolonein the treatment of keloids. Nasrin SakiRaya MokhtariFarnoosh NozariMattioli1885articlekeloidverapamiltriamcinoloneVancouver Scar ScalescarDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	keloid verapamil triamcinolone Vancouver Scar Scale scar Dermatology RL1-803
spellingShingle	keloid verapamil triamcinolone Vancouver Scar Scale scar Dermatology RL1-803 Nasrin Saki Raya Mokhtari Farnoosh Nozari Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
description	Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Sporadic reports on the use of intralesional verapamil suggest its efficacy. Aim: Since there is not sufficient evidence to support the role of intralesional verapamil as an effective alternative modality, it was decided to undertake a randomized study to determine its efficacy as a treatment for keloids. Methods: A randomized, single-blind, single-group comparison with 15 patients (30 scars) was carried out to compare the effects of intralesional triamcinolone with verapamil injections. Injections were scheduled every 3 weeks accompanied by cryotherapy until complete flattening of the scar or maximum 8 sessions, whichever came earlier. Scar evaluation at each stage was done by serial photographic records as well as by Vancouver scar scale. Statistical analysis was done by Wilcoxon and Mann-Whitney U tests using SPSS version 19. Results: In both study groups there was a reduction in height and pliability at the end of the study. Better improvement in height and pliability was seen with triamcinolone in comparison with verapamil. However, a desired change in vascularity and pigmentation was not seen with either of the drugs. Conclusion: Verapamilis not as effective as triamcinolonein the treatment of keloids.
format	article
author	Nasrin Saki Raya Mokhtari Farnoosh Nozari
author_facet	Nasrin Saki Raya Mokhtari Farnoosh Nozari
author_sort	Nasrin Saki
title	Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
title_short	Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
title_full	Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
title_fullStr	Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
title_full_unstemmed	Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial
title_sort	comparing the efficacy of intralesional triamcinolone acetonide with verapamil in treatment of keloids: a randomized controlled trial
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/42aaaac573db42aa9eaa64d41a8836c3
work_keys_str_mv	AT nasrinsaki comparingtheefficacyofintralesionaltriamcinoloneacetonidewithverapamilintreatmentofkeloidsarandomizedcontrolledtrial AT rayamokhtari comparingtheefficacyofintralesionaltriamcinoloneacetonidewithverapamilintreatmentofkeloidsarandomizedcontrolledtrial AT farnooshnozari comparingtheefficacyofintralesionaltriamcinoloneacetonidewithverapamilintreatmentofkeloidsarandomizedcontrolledtrial
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Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial

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