Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis

Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody...

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Autores principales:	Sarah R. Barger, Nicholas S. Reilly, Maria S. Shutova, Qingsen Li, Paolo Maiuri, John M. Heddleston, Mark S. Mooseker, Richard A. Flavell, Tatyana Svitkina, Patrick W. Oakes, Mira Krendel, Nils C. Gauthier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42adf260ea6c448fbdbf17cfb3eda9f6
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spelling	oai:doaj.org-article:42adf260ea6c448fbdbf17cfb3eda9f62021-12-02T14:39:17ZMembrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis10.1038/s41467-019-09104-12041-1723https://doaj.org/article/42adf260ea6c448fbdbf17cfb3eda9f62019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09104-1https://doaj.org/toc/2041-1723Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets.Sarah R. BargerNicholas S. ReillyMaria S. ShutovaQingsen LiPaolo MaiuriJohn M. HeddlestonMark S. MoosekerRichard A. FlavellTatyana SvitkinaPatrick W. OakesMira KrendelNils C. GauthierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah R. Barger Nicholas S. Reilly Maria S. Shutova Qingsen Li Paolo Maiuri John M. Heddleston Mark S. Mooseker Richard A. Flavell Tatyana Svitkina Patrick W. Oakes Mira Krendel Nils C. Gauthier Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
description	Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets.
format	article
author	Sarah R. Barger Nicholas S. Reilly Maria S. Shutova Qingsen Li Paolo Maiuri John M. Heddleston Mark S. Mooseker Richard A. Flavell Tatyana Svitkina Patrick W. Oakes Mira Krendel Nils C. Gauthier
author_facet	Sarah R. Barger Nicholas S. Reilly Maria S. Shutova Qingsen Li Paolo Maiuri John M. Heddleston Mark S. Mooseker Richard A. Flavell Tatyana Svitkina Patrick W. Oakes Mira Krendel Nils C. Gauthier
author_sort	Sarah R. Barger
title	Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
title_short	Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
title_full	Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
title_fullStr	Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
title_full_unstemmed	Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
title_sort	membrane-cytoskeletal crosstalk mediated by myosin-i regulates adhesion turnover during phagocytosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/42adf260ea6c448fbdbf17cfb3eda9f6
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Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis

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