Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).

Microevolution of Puumala hantavirus (PUUV) was studied throughout a population cycle of its host, the bank vole (Myodes glareolus). We monitored PUUV variants circulating in the host population in Central Finland over a five-year period that included two peak-phases and two population declines. Of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Razzauti, Angelina Plyusnina, Heikki Henttonen, Alexander Plyusnin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42b119dc6a5e43f293d214b2f8d895a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:42b119dc6a5e43f293d214b2f8d895a4
record_format	dspace
spelling	oai:doaj.org-article:42b119dc6a5e43f293d214b2f8d895a42021-11-18T07:44:32ZMicroevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).1932-620310.1371/journal.pone.0064447https://doaj.org/article/42b119dc6a5e43f293d214b2f8d895a42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717616/?tool=EBIhttps://doaj.org/toc/1932-6203Microevolution of Puumala hantavirus (PUUV) was studied throughout a population cycle of its host, the bank vole (Myodes glareolus). We monitored PUUV variants circulating in the host population in Central Finland over a five-year period that included two peak-phases and two population declines. Of 1369 bank voles examined, 360 (26.3%) were found infected with PUUV. Partial sequences of each of the three genome segments were recovered (approx. 12% of PUUV genome) from 356 bank voles. Analyses of these sequences disclosed the following features of PUUV evolution: 1) nucleotide substitutions are mostly silent and deduced amino acid changes are mainly conservative, suggesting stabilizing selection at the protein level; 2) the three genome segments accumulate mutations at a different rate; 3) some of the circulating PUUV variants are frequently observed while others are transient; 4) frequently occurring PUUV variants are composed of the most abundant segment genotypes (copious) and new transient variants are continually generated; 5) reassortment of PUUV genome segments occurs regularly and follows a specific pattern of segments association; 6) prevalence of reassortant variants oscillates with season and is higher in the autumn than in the spring; and 7) reassortants are transient, i.e., they are not competitively superior to their parental variants. Collectively, these observations support a quasi-neutral mode of PUUV microevolution with a steady generation of transient variants, including reassortants, and preservation of a few preferred genotypes.Maria RazzautiAngelina PlyusninaHeikki HenttonenAlexander PlyusninPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64447 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Razzauti Angelina Plyusnina Heikki Henttonen Alexander Plyusnin Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
description	Microevolution of Puumala hantavirus (PUUV) was studied throughout a population cycle of its host, the bank vole (Myodes glareolus). We monitored PUUV variants circulating in the host population in Central Finland over a five-year period that included two peak-phases and two population declines. Of 1369 bank voles examined, 360 (26.3%) were found infected with PUUV. Partial sequences of each of the three genome segments were recovered (approx. 12% of PUUV genome) from 356 bank voles. Analyses of these sequences disclosed the following features of PUUV evolution: 1) nucleotide substitutions are mostly silent and deduced amino acid changes are mainly conservative, suggesting stabilizing selection at the protein level; 2) the three genome segments accumulate mutations at a different rate; 3) some of the circulating PUUV variants are frequently observed while others are transient; 4) frequently occurring PUUV variants are composed of the most abundant segment genotypes (copious) and new transient variants are continually generated; 5) reassortment of PUUV genome segments occurs regularly and follows a specific pattern of segments association; 6) prevalence of reassortant variants oscillates with season and is higher in the autumn than in the spring; and 7) reassortants are transient, i.e., they are not competitively superior to their parental variants. Collectively, these observations support a quasi-neutral mode of PUUV microevolution with a steady generation of transient variants, including reassortants, and preservation of a few preferred genotypes.
format	article
author	Maria Razzauti Angelina Plyusnina Heikki Henttonen Alexander Plyusnin
author_facet	Maria Razzauti Angelina Plyusnina Heikki Henttonen Alexander Plyusnin
author_sort	Maria Razzauti
title	Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
title_short	Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
title_full	Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
title_fullStr	Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
title_full_unstemmed	Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).
title_sort	microevolution of puumala hantavirus during a complete population cycle of its host, the bank vole (myodes glareolus).
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/42b119dc6a5e43f293d214b2f8d895a4
work_keys_str_mv	AT mariarazzauti microevolutionofpuumalahantavirusduringacompletepopulationcycleofitshostthebankvolemyodesglareolus AT angelinaplyusnina microevolutionofpuumalahantavirusduringacompletepopulationcycleofitshostthebankvolemyodesglareolus AT heikkihenttonen microevolutionofpuumalahantavirusduringacompletepopulationcycleofitshostthebankvolemyodesglareolus AT alexanderplyusnin microevolutionofpuumalahantavirusduringacompletepopulationcycleofitshostthebankvolemyodesglareolus
_version_	1718423031583342592

Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus).

Ejemplares similares