Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of ch...

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Autores principales:	Ana Sofía Herrera-Van Oostdam, Mariana Salgado-Bustamante, Victoria Lima-Rogel, Juan José Oropeza-Valdez, Jesús Adrián López, Iván Daniel Román Rodríguez, Juan Carlos Toro-Ortiz, David Alejandro Herrera-Van Oostdam, Yamilé López-Hernández, Joel Monárez-Espino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	newborns metabolomics gestational diabetes pregnancy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/42b25e9e62664e87b609e013a02faf18
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spelling	oai:doaj.org-article:42b25e9e62664e87b609e013a02faf182021-11-25T18:20:28ZUrinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus10.3390/metabo111107232218-1989https://doaj.org/article/42b25e9e62664e87b609e013a02faf182021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/723https://doaj.org/toc/2218-1989Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of chronic diseases later in adult life. In this study, the urinary metabolome of babies born to GDM mothers was characterized. In total, 144 neonatal and maternal (second and third trimesters of pregnancy) urinary samples were analyzed using targeted metabolomics, combining liquid chromatographic mass spectrometry (LC-MS/MS) and flow injection analysis mass spectrometry (FIA-MS/MS) techniques. We provide here the neonatal urinary concentration values of 101 metabolites for 26 newborns born to GDM mothers and 22 newborns born to healthy mothers. The univariate analysis of these metabolites revealed statistical differences in 11 metabolites. Multivariate analyses revealed a differential metabolic profile in newborns of GDM mothers characterized by dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Levels of hexadecenoylcarnitine (C16:1) and spermine were also higher in newborns of GDM mothers. The maternal urinary metabolome revealed significant differences in butyric, isobutyric, and uric acid in the second and third trimesters of pregnancy. These metabolic alterations point to the impact of GDM in the neonatal period.Ana Sofía Herrera-Van OostdamMariana Salgado-BustamanteVictoria Lima-RogelJuan José Oropeza-ValdezJesús Adrián LópezIván Daniel Román RodríguezJuan Carlos Toro-OrtizDavid Alejandro Herrera-Van OostdamYamilé López-HernándezJoel Monárez-EspinoMDPI AGarticlenewbornsmetabolomicsgestational diabetespregnancyMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 723, p 723 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	newborns metabolomics gestational diabetes pregnancy Microbiology QR1-502
spellingShingle	newborns metabolomics gestational diabetes pregnancy Microbiology QR1-502 Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárez-Espino Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
description	Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of chronic diseases later in adult life. In this study, the urinary metabolome of babies born to GDM mothers was characterized. In total, 144 neonatal and maternal (second and third trimesters of pregnancy) urinary samples were analyzed using targeted metabolomics, combining liquid chromatographic mass spectrometry (LC-MS/MS) and flow injection analysis mass spectrometry (FIA-MS/MS) techniques. We provide here the neonatal urinary concentration values of 101 metabolites for 26 newborns born to GDM mothers and 22 newborns born to healthy mothers. The univariate analysis of these metabolites revealed statistical differences in 11 metabolites. Multivariate analyses revealed a differential metabolic profile in newborns of GDM mothers characterized by dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Levels of hexadecenoylcarnitine (C16:1) and spermine were also higher in newborns of GDM mothers. The maternal urinary metabolome revealed significant differences in butyric, isobutyric, and uric acid in the second and third trimesters of pregnancy. These metabolic alterations point to the impact of GDM in the neonatal period.
format	article
author	Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárez-Espino
author_facet	Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárez-Espino
author_sort	Ana Sofía Herrera-Van Oostdam
title	Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
title_short	Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
title_full	Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
title_fullStr	Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
title_full_unstemmed	Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
title_sort	urinary metabolomic profile of neonates born to women with gestational diabetes mellitus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/42b25e9e62664e87b609e013a02faf18
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Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus

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