TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity

Transport protein particle (TRAPP) is a multimeric protein complex regulating membrane trafficking pathways. Here the authors show that TRAPPC4, a core subunit of TRAPP complex, is required for RAB11-mediated recycling of PD-L1, affecting T-cell-mediated anti-tumor immune responses.

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Autores principales:	Yimeng Ren, Yun Qian, Luoyan Ai, Yile Xie, Yaqi Gao, Ziyan Zhuang, Jinxian Chen, Ying-Xuan Chen, Jing-Yuan Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42b747d961694a008ae75ed740330fe4
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spelling	oai:doaj.org-article:42b747d961694a008ae75ed740330fe42021-12-02T15:31:28ZTRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity10.1038/s41467-021-25662-92041-1723https://doaj.org/article/42b747d961694a008ae75ed740330fe42021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25662-9https://doaj.org/toc/2041-1723Transport protein particle (TRAPP) is a multimeric protein complex regulating membrane trafficking pathways. Here the authors show that TRAPPC4, a core subunit of TRAPP complex, is required for RAB11-mediated recycling of PD-L1, affecting T-cell-mediated anti-tumor immune responses.Yimeng RenYun QianLuoyan AiYile XieYaqi GaoZiyan ZhuangJinxian ChenYing-Xuan ChenJing-Yuan FangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yimeng Ren Yun Qian Luoyan Ai Yile Xie Yaqi Gao Ziyan Zhuang Jinxian Chen Ying-Xuan Chen Jing-Yuan Fang TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
description	Transport protein particle (TRAPP) is a multimeric protein complex regulating membrane trafficking pathways. Here the authors show that TRAPPC4, a core subunit of TRAPP complex, is required for RAB11-mediated recycling of PD-L1, affecting T-cell-mediated anti-tumor immune responses.
format	article
author	Yimeng Ren Yun Qian Luoyan Ai Yile Xie Yaqi Gao Ziyan Zhuang Jinxian Chen Ying-Xuan Chen Jing-Yuan Fang
author_facet	Yimeng Ren Yun Qian Luoyan Ai Yile Xie Yaqi Gao Ziyan Zhuang Jinxian Chen Ying-Xuan Chen Jing-Yuan Fang
author_sort	Yimeng Ren
title	TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
title_short	TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
title_full	TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
title_fullStr	TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
title_full_unstemmed	TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
title_sort	trappc4 regulates the intracellular trafficking of pd-l1 and antitumor immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42b747d961694a008ae75ed740330fe4
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TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity

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