Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

ABSTRACT We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, th...

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Auteurs principaux: Kien Nguyen, Biswajit Das, Curtis Dobrowolski, Jonathan Karn
Format: article
Langue:EN
Publié: American Society for Microbiology 2017
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Accès en ligne:https://doaj.org/article/42bc129c3b064471b3b996f5b6bbbf29
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