Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study

Background. Venous thromboembolism (VTE) is referred to as formation of clots in a deep vein or lodging of thrombus towards the lungs which could be fatal yet preventable. The risk of developing VTE can be increased by various factors. Where there are innumerable acquired causes, the possibility of...

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Autores principales:	Maria Khan, Chaudhry Altaf, Hamid Saeed Malik, Muhammad Abdul Naeem, Aamna Latif
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/42bc8baf3ae74c139ed87eacbb2c3e6b
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spelling	oai:doaj.org-article:42bc8baf3ae74c139ed87eacbb2c3e6b2021-11-08T02:36:52ZHeritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study1687-911210.1155/2021/8317605https://doaj.org/article/42bc8baf3ae74c139ed87eacbb2c3e6b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8317605https://doaj.org/toc/1687-9112Background. Venous thromboembolism (VTE) is referred to as formation of clots in a deep vein or lodging of thrombus towards the lungs which could be fatal yet preventable. The risk of developing VTE can be increased by various factors. Where there are innumerable acquired causes, the possibility of inherited thrombophilia cannot be ignored. In view of this, we have evaluated all patients with venous thromboembolism for inherited thrombophilia. Objective. To evaluate the frequencies of antithrombin (AT) deficiency, protein C and S deficiencies, Factor V Leiden, and prothrombin gene mutations in patients harboring venous thromboembolism. Materials and Methods. A study comprising of 880 patients who were presented with manifestations of venous thromboembolism was conducted from July 2016 to June 2017. A blood sample collected from patients was screened for thrombophilia defects encompassing AT, protein C and S deficiencies, Factor V Leiden, and prothrombin gene mutations. All acquired causes of thrombosis were excluded. Results. Of 880 patients who underwent screening for thrombophilia, 182 patients demonstrated VTE history. Their age ranged from 1 to 58 years. Males constituted a predominant group. About 45 (24.7%) patients had evidence of heritable thrombophilia. Of these, 20 (10.9%) had AT deficiency, 9 (4.9%) had Factor V Leiden mutation, 6 (3.2%) had protein C deficiency, whereas protein S deficiency and prothrombin gene mutation both were found in 5 (2.7%) patients. Conclusion. Our study illustrated the highest frequency of antithrombin deficiency among other investigated thrombophilia defects.Maria KhanChaudhry AltafHamid Saeed MalikMuhammad Abdul NaeemAamna LatifHindawi LimitedarticleDiseases of the blood and blood-forming organsRC633-647.5ENAdvances in Hematology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Maria Khan Chaudhry Altaf Hamid Saeed Malik Muhammad Abdul Naeem Aamna Latif Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
description	Background. Venous thromboembolism (VTE) is referred to as formation of clots in a deep vein or lodging of thrombus towards the lungs which could be fatal yet preventable. The risk of developing VTE can be increased by various factors. Where there are innumerable acquired causes, the possibility of inherited thrombophilia cannot be ignored. In view of this, we have evaluated all patients with venous thromboembolism for inherited thrombophilia. Objective. To evaluate the frequencies of antithrombin (AT) deficiency, protein C and S deficiencies, Factor V Leiden, and prothrombin gene mutations in patients harboring venous thromboembolism. Materials and Methods. A study comprising of 880 patients who were presented with manifestations of venous thromboembolism was conducted from July 2016 to June 2017. A blood sample collected from patients was screened for thrombophilia defects encompassing AT, protein C and S deficiencies, Factor V Leiden, and prothrombin gene mutations. All acquired causes of thrombosis were excluded. Results. Of 880 patients who underwent screening for thrombophilia, 182 patients demonstrated VTE history. Their age ranged from 1 to 58 years. Males constituted a predominant group. About 45 (24.7%) patients had evidence of heritable thrombophilia. Of these, 20 (10.9%) had AT deficiency, 9 (4.9%) had Factor V Leiden mutation, 6 (3.2%) had protein C deficiency, whereas protein S deficiency and prothrombin gene mutation both were found in 5 (2.7%) patients. Conclusion. Our study illustrated the highest frequency of antithrombin deficiency among other investigated thrombophilia defects.
format	article
author	Maria Khan Chaudhry Altaf Hamid Saeed Malik Muhammad Abdul Naeem Aamna Latif
author_facet	Maria Khan Chaudhry Altaf Hamid Saeed Malik Muhammad Abdul Naeem Aamna Latif
author_sort	Maria Khan
title	Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
title_short	Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
title_full	Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
title_fullStr	Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
title_full_unstemmed	Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study
title_sort	heritable thrombophilia in venous thromboembolism in northern pakistan: a cross-sectional study
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/42bc8baf3ae74c139ed87eacbb2c3e6b
work_keys_str_mv	AT mariakhan heritablethrombophiliainvenousthromboembolisminnorthernpakistanacrosssectionalstudy AT chaudhryaltaf heritablethrombophiliainvenousthromboembolisminnorthernpakistanacrosssectionalstudy AT hamidsaeedmalik heritablethrombophiliainvenousthromboembolisminnorthernpakistanacrosssectionalstudy AT muhammadabdulnaeem heritablethrombophiliainvenousthromboembolisminnorthernpakistanacrosssectionalstudy AT aamnalatif heritablethrombophiliainvenousthromboembolisminnorthernpakistanacrosssectionalstudy
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Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study

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