Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis

Supplementation with nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors including dietary nicotinamide has been found to boost tissue NAD<sup>+</sup> levels and ameliorate oxidative stress-induced damage that contributes to aging and aging-related diseases. The as...

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Autores principales:	Wenbo Wu, Martijn J. L. Bours, Annaleen Koole, Marlou-Floor Kenkhuis, Simone J. P. M. Eussen, Stephanie O. Breukink, Frederik-Jan van Schooten, Matty P. Weijenberg, Geja J. Hageman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer survivor fatigue patient-reported outcomes nicotinamide NAD<sup>+</sup> precursor Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/42be89a8e2914fee8cd5ee316f5af4a5
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spelling	oai:doaj.org-article:42be89a8e2914fee8cd5ee316f5af4a52021-11-25T18:33:20ZCross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis10.3390/nu131137072072-6643https://doaj.org/article/42be89a8e2914fee8cd5ee316f5af4a52021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3707https://doaj.org/toc/2072-6643Supplementation with nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors including dietary nicotinamide has been found to boost tissue NAD<sup>+</sup> levels and ameliorate oxidative stress-induced damage that contributes to aging and aging-related diseases. The association between dietary NAD<sup>+</sup> precursors and patient-reported health-related outcomes in cancer survivors has not been investigated. This study aimed to determine associations of dietary nicotinamide intake with different patient-reported outcomes in colorectal cancer survivors, 2 to 10 years post-diagnosis. A total of 145 eligible participants were recruited into this cross-sectional study. Dietary nicotinamide intake level was calculated based on data from 7-day food diaries. Fatigue was assessed with the Checklist Individual Strength (CIS), which is a subscale of the cancer-specific European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC), and anxiety and depression were assessed with Hospital Anxiety and Depression Scale (HADS). Oxidative stress marker serum protein carbonyl contents and serum NAD<sup>+</sup> levels were measured. A hierarchical linear regression model with confounder adjustment was performed to analyze the association of nicotinamide intake, serum protein carbonyl contents, and NAD<sup>+</sup> levels with patient-reported outcomes. The median values of daily nicotinamide intake for male and female participants were 19.1 and 14.4 mg, respectively. Daily dietary nicotinamide intake was associated with a lower level of fatigue (β: −14.85 (−28.14, −1.56)) and a lower level of anxiety and depression (β: −4.69 (−8.55, −0.83)). Subgroup analyses by sex showed that a beneficial association between nicotinamide intake and patient-reported outcomes was mainly found in men. To conclude, our findings suggested that higher dietary NAD<sup>+</sup> precursor nicotinamide intake was cross-sectionally associated with less patient-reported outcomes in CRC survivors.Wenbo WuMartijn J. L. BoursAnnaleen KooleMarlou-Floor KenkhuisSimone J. P. M. EussenStephanie O. BreukinkFrederik-Jan van SchootenMatty P. WeijenbergGeja J. HagemanMDPI AGarticlecolorectal cancer survivorfatiguepatient-reported outcomesnicotinamideNAD<sup>+</sup> precursorNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3707, p 3707 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer survivor fatigue patient-reported outcomes nicotinamide NAD<sup>+</sup> precursor Nutrition. Foods and food supply TX341-641
spellingShingle	colorectal cancer survivor fatigue patient-reported outcomes nicotinamide NAD<sup>+</sup> precursor Nutrition. Foods and food supply TX341-641 Wenbo Wu Martijn J. L. Bours Annaleen Koole Marlou-Floor Kenkhuis Simone J. P. M. Eussen Stephanie O. Breukink Frederik-Jan van Schooten Matty P. Weijenberg Geja J. Hageman Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
description	Supplementation with nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors including dietary nicotinamide has been found to boost tissue NAD<sup>+</sup> levels and ameliorate oxidative stress-induced damage that contributes to aging and aging-related diseases. The association between dietary NAD<sup>+</sup> precursors and patient-reported health-related outcomes in cancer survivors has not been investigated. This study aimed to determine associations of dietary nicotinamide intake with different patient-reported outcomes in colorectal cancer survivors, 2 to 10 years post-diagnosis. A total of 145 eligible participants were recruited into this cross-sectional study. Dietary nicotinamide intake level was calculated based on data from 7-day food diaries. Fatigue was assessed with the Checklist Individual Strength (CIS), which is a subscale of the cancer-specific European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC), and anxiety and depression were assessed with Hospital Anxiety and Depression Scale (HADS). Oxidative stress marker serum protein carbonyl contents and serum NAD<sup>+</sup> levels were measured. A hierarchical linear regression model with confounder adjustment was performed to analyze the association of nicotinamide intake, serum protein carbonyl contents, and NAD<sup>+</sup> levels with patient-reported outcomes. The median values of daily nicotinamide intake for male and female participants were 19.1 and 14.4 mg, respectively. Daily dietary nicotinamide intake was associated with a lower level of fatigue (β: −14.85 (−28.14, −1.56)) and a lower level of anxiety and depression (β: −4.69 (−8.55, −0.83)). Subgroup analyses by sex showed that a beneficial association between nicotinamide intake and patient-reported outcomes was mainly found in men. To conclude, our findings suggested that higher dietary NAD<sup>+</sup> precursor nicotinamide intake was cross-sectionally associated with less patient-reported outcomes in CRC survivors.
format	article
author	Wenbo Wu Martijn J. L. Bours Annaleen Koole Marlou-Floor Kenkhuis Simone J. P. M. Eussen Stephanie O. Breukink Frederik-Jan van Schooten Matty P. Weijenberg Geja J. Hageman
author_facet	Wenbo Wu Martijn J. L. Bours Annaleen Koole Marlou-Floor Kenkhuis Simone J. P. M. Eussen Stephanie O. Breukink Frederik-Jan van Schooten Matty P. Weijenberg Geja J. Hageman
author_sort	Wenbo Wu
title	Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
title_short	Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
title_full	Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
title_fullStr	Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
title_full_unstemmed	Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis
title_sort	cross-sectional associations between dietary daily nicotinamide intake and patient-reported outcomes in colorectal cancer survivors, 2 to 10 years post-diagnosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/42be89a8e2914fee8cd5ee316f5af4a5
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Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis

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