The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with asbestos exposure and is characterized by a very difficult pharmacological approach. One of the molecular mechanisms associated with cancer onset and invasiveness is the epithelial-to-mesenchymal transition (EMT), an...

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Autores principales: Valeria Ramundo, Giada Zanirato, Elisabetta Aldieri
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:42c0face28254aa2be51d9e37dec4e372021-11-25T17:54:24ZThe Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma10.3390/ijms2222122161422-00671661-6596https://doaj.org/article/42c0face28254aa2be51d9e37dec4e372021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12216https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with asbestos exposure and is characterized by a very difficult pharmacological approach. One of the molecular mechanisms associated with cancer onset and invasiveness is the epithelial-to-mesenchymal transition (EMT), an event induced by different types of inducers, such as transforming growth factor β (TGFβ), the main inducer of EMT, and oxidative stress. MPM development and metastasis have been correlated to EMT; On one hand, EMT mediates the effects exerted by asbestos fibers in the mesothelium, particularly via increased oxidative stress and TGFβ levels evoked by asbestos exposure, thus promoting a malignant phenotype, and on the other hand, MPM acquires invasiveness via the EMT event, as shown by an upregulation of mesenchymal markers or, although indirectly, some miRNAs or non-coding RNAs, all demonstrated to be involved in cancer onset and metastasis. This review aims to better describe how EMT is involved in driving the development and invasiveness of MPM, in an attempt to open new scenarios that are useful in the identification of predictive markers and to improve the pharmacological approach against this aggressive cancer.Valeria RamundoGiada ZaniratoElisabetta AldieriMDPI AGarticleepithelial mesenchymal transitionmalignant pleural mesotheliomatransforming growth factor βoxidative stressmiRNAsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12216, p 12216 (2021)
institution DOAJ
collection DOAJ
language EN
topic epithelial mesenchymal transition
malignant pleural mesothelioma
transforming growth factor β
oxidative stress
miRNAs
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle epithelial mesenchymal transition
malignant pleural mesothelioma
transforming growth factor β
oxidative stress
miRNAs
Biology (General)
QH301-705.5
Chemistry
QD1-999
Valeria Ramundo
Giada Zanirato
Elisabetta Aldieri
The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
description Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with asbestos exposure and is characterized by a very difficult pharmacological approach. One of the molecular mechanisms associated with cancer onset and invasiveness is the epithelial-to-mesenchymal transition (EMT), an event induced by different types of inducers, such as transforming growth factor β (TGFβ), the main inducer of EMT, and oxidative stress. MPM development and metastasis have been correlated to EMT; On one hand, EMT mediates the effects exerted by asbestos fibers in the mesothelium, particularly via increased oxidative stress and TGFβ levels evoked by asbestos exposure, thus promoting a malignant phenotype, and on the other hand, MPM acquires invasiveness via the EMT event, as shown by an upregulation of mesenchymal markers or, although indirectly, some miRNAs or non-coding RNAs, all demonstrated to be involved in cancer onset and metastasis. This review aims to better describe how EMT is involved in driving the development and invasiveness of MPM, in an attempt to open new scenarios that are useful in the identification of predictive markers and to improve the pharmacological approach against this aggressive cancer.
format article
author Valeria Ramundo
Giada Zanirato
Elisabetta Aldieri
author_facet Valeria Ramundo
Giada Zanirato
Elisabetta Aldieri
author_sort Valeria Ramundo
title The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
title_short The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
title_full The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
title_fullStr The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
title_full_unstemmed The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma
title_sort epithelial-to-mesenchymal transition (emt) in the development and metastasis of malignant pleural mesothelioma
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/42c0face28254aa2be51d9e37dec4e37
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