Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achi...

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Autores principales: Patrick A. Baeuerle, Jian Ding, Ekta Patel, Niko Thorausch, Holly Horton, Jessica Gierut, Irene Scarfo, Rashmi Choudhary, Olga Kiner, Janani Krishnamurthy, Bonnie Le, Anna Morath, G. Christian Baldeviano, Justin Quinn, Patrick Tavares, Qi Wei, Solly Weiler, Marcela V. Maus, Daniel Getts, Wolfgang W. Schamel, Robert Hofmeister
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b
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Sumario:Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.

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