Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achi...

Full description

Saved in:
Bibliographic Details
Main Authors: Patrick A. Baeuerle, Jian Ding, Ekta Patel, Niko Thorausch, Holly Horton, Jessica Gierut, Irene Scarfo, Rashmi Choudhary, Olga Kiner, Janani Krishnamurthy, Bonnie Le, Anna Morath, G. Christian Baldeviano, Justin Quinn, Patrick Tavares, Qi Wei, Solly Weiler, Marcela V. Maus, Daniel Getts, Wolfgang W. Schamel, Robert Hofmeister
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.

Similar Items