Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achi...

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Autores principales:	Patrick A. Baeuerle, Jian Ding, Ekta Patel, Niko Thorausch, Holly Horton, Jessica Gierut, Irene Scarfo, Rashmi Choudhary, Olga Kiner, Janani Krishnamurthy, Bonnie Le, Anna Morath, G. Christian Baldeviano, Justin Quinn, Patrick Tavares, Qi Wei, Solly Weiler, Marcela V. Maus, Daniel Getts, Wolfgang W. Schamel, Robert Hofmeister
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:42c1e735be344a329bcc2474e5dbd81b2021-12-02T16:58:18ZSynthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response10.1038/s41467-019-10097-02041-1723https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10097-0https://doaj.org/toc/2041-1723Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.Patrick A. BaeuerleJian DingEkta PatelNiko ThorauschHolly HortonJessica GierutIrene ScarfoRashmi ChoudharyOlga KinerJanani KrishnamurthyBonnie LeAnna MorathG. Christian BaldevianoJustin QuinnPatrick TavaresQi WeiSolly WeilerMarcela V. MausDaniel GettsWolfgang W. SchamelRobert HofmeisterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick A. Baeuerle Jian Ding Ekta Patel Niko Thorausch Holly Horton Jessica Gierut Irene Scarfo Rashmi Choudhary Olga Kiner Janani Krishnamurthy Bonnie Le Anna Morath G. Christian Baldeviano Justin Quinn Patrick Tavares Qi Wei Solly Weiler Marcela V. Maus Daniel Getts Wolfgang W. Schamel Robert Hofmeister Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
description	Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.
format	article
author	Patrick A. Baeuerle Jian Ding Ekta Patel Niko Thorausch Holly Horton Jessica Gierut Irene Scarfo Rashmi Choudhary Olga Kiner Janani Krishnamurthy Bonnie Le Anna Morath G. Christian Baldeviano Justin Quinn Patrick Tavares Qi Wei Solly Weiler Marcela V. Maus Daniel Getts Wolfgang W. Schamel Robert Hofmeister
author_facet	Patrick A. Baeuerle Jian Ding Ekta Patel Niko Thorausch Holly Horton Jessica Gierut Irene Scarfo Rashmi Choudhary Olga Kiner Janani Krishnamurthy Bonnie Le Anna Morath G. Christian Baldeviano Justin Quinn Patrick Tavares Qi Wei Solly Weiler Marcela V. Maus Daniel Getts Wolfgang W. Schamel Robert Hofmeister
author_sort	Patrick A. Baeuerle
title	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
title_short	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
title_full	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
title_fullStr	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
title_full_unstemmed	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
title_sort	synthetic truc receptors engaging the complete t cell receptor for potent anti-tumor response
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b
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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

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