A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach

Abstract Background Primary squamous cell carcinoma (SCC) of stomach is extremely rare. The pathogenesis of SCC of stomach remains unclear. There is only one report that Epstein Barr virus (EBV) infection may be involved in the pathogenesis of SCC arising in the stomach ever before. Here, we report...

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Autores principales:	Yuki Katsura, Takehiro Okabayashi, Kazuhiro Ozaki, Yuichi Shibuya, Jun Iwata
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Squamous cell carcinoma Stomach neoplasms Epstein Barr virus Surgery RD1-811
Acceso en línea:	https://doaj.org/article/42cb02c0ae3a4ed4b94a50d5e0cd63fb
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spelling	oai:doaj.org-article:42cb02c0ae3a4ed4b94a50d5e0cd63fb2021-11-21T12:31:54ZA case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach10.1186/s40792-021-01301-92198-7793https://doaj.org/article/42cb02c0ae3a4ed4b94a50d5e0cd63fb2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40792-021-01301-9https://doaj.org/toc/2198-7793Abstract Background Primary squamous cell carcinoma (SCC) of stomach is extremely rare. The pathogenesis of SCC of stomach remains unclear. There is only one report that Epstein Barr virus (EBV) infection may be involved in the pathogenesis of SCC arising in the stomach ever before. Here, we report a case of Epstein Barr virus infection-associated primary SCC of stomach in a 70-year-old woman. She was presented to the referring hospital with hematemesis. Initial endoscopy revealed a bleeding gastric ulcer in the upper part of gastric corpus and the coagulation therapy was followed. After a 3-month follow-up, endoscopy revealed a submucosal tumor-like protrusion instead of an ulcer. Computed tomography revealed a mass in the upper part of stomach and swollen lymph nodes along with the lesser curvature and para-aortic lymph node. Biopsy could not confirm the definitive diagnosis. We performed total gastrectomy with para-aortic lymph node sampling. Histological analysis revealed squamous cell carcinoma with EBV infection with lymph node metastases. Tumor cells were positive for EBV-encoded small RNA (EBER) by in situ hybridization. The postoperative course was uneventful and the patient was discharged on day 11 after the operation. CapeOX was started as adjuvant chemotherapy, and the patient remains alive without recurrence 7 months after surgery. Conclusion This is the first case report of EBV infection-associated primary SCC of the stomach diagnosed by in situ hybridization of EBER. EBV infection may be related to the pathogenesis of primary SCC. Further evidence and studies are required to establish optimal strategy for this rare disease.Yuki KatsuraTakehiro OkabayashiKazuhiro OzakiYuichi ShibuyaJun IwataSpringerOpenarticleSquamous cell carcinomaStomach neoplasmsEpstein Barr virusSurgeryRD1-811ENSurgical Case Reports, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Squamous cell carcinoma Stomach neoplasms Epstein Barr virus Surgery RD1-811
spellingShingle	Squamous cell carcinoma Stomach neoplasms Epstein Barr virus Surgery RD1-811 Yuki Katsura Takehiro Okabayashi Kazuhiro Ozaki Yuichi Shibuya Jun Iwata A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
description	Abstract Background Primary squamous cell carcinoma (SCC) of stomach is extremely rare. The pathogenesis of SCC of stomach remains unclear. There is only one report that Epstein Barr virus (EBV) infection may be involved in the pathogenesis of SCC arising in the stomach ever before. Here, we report a case of Epstein Barr virus infection-associated primary SCC of stomach in a 70-year-old woman. She was presented to the referring hospital with hematemesis. Initial endoscopy revealed a bleeding gastric ulcer in the upper part of gastric corpus and the coagulation therapy was followed. After a 3-month follow-up, endoscopy revealed a submucosal tumor-like protrusion instead of an ulcer. Computed tomography revealed a mass in the upper part of stomach and swollen lymph nodes along with the lesser curvature and para-aortic lymph node. Biopsy could not confirm the definitive diagnosis. We performed total gastrectomy with para-aortic lymph node sampling. Histological analysis revealed squamous cell carcinoma with EBV infection with lymph node metastases. Tumor cells were positive for EBV-encoded small RNA (EBER) by in situ hybridization. The postoperative course was uneventful and the patient was discharged on day 11 after the operation. CapeOX was started as adjuvant chemotherapy, and the patient remains alive without recurrence 7 months after surgery. Conclusion This is the first case report of EBV infection-associated primary SCC of the stomach diagnosed by in situ hybridization of EBER. EBV infection may be related to the pathogenesis of primary SCC. Further evidence and studies are required to establish optimal strategy for this rare disease.
format	article
author	Yuki Katsura Takehiro Okabayashi Kazuhiro Ozaki Yuichi Shibuya Jun Iwata
author_facet	Yuki Katsura Takehiro Okabayashi Kazuhiro Ozaki Yuichi Shibuya Jun Iwata
author_sort	Yuki Katsura
title	A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
title_short	A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
title_full	A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
title_fullStr	A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
title_full_unstemmed	A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
title_sort	case of epstein barr virus-associated primary squamous cell carcinoma of stomach
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/42cb02c0ae3a4ed4b94a50d5e0cd63fb
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A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach

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