Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging

Verônica Castro Lima,1,2 Richard B Rosen,1,3 Tiago Santos Prata,2 Syril Dorairaj,4 Leigh Spielberg,1 Mauricio Maia,2 Juliana M Sallum21Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY, 2Department of Ophthalmology, Federal University of S&at...

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Autores principales:	Lima VC, Rosen RB, Prata TS, Dorairaj S, Spielberg L, Maia M, Sallum JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/42ccf806c10546d8be9e124c6d318b44
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spelling	oai:doaj.org-article:42ccf806c10546d8be9e124c6d318b442021-12-02T01:28:23ZAssociation of age and macular pigment optical density using dual-wavelength autofluorescence imaging1177-54671177-5483https://doaj.org/article/42ccf806c10546d8be9e124c6d318b442013-04-01T00:00:00Zhttp://www.dovepress.com/association-of-age-and-macular-pigment-optical-density-using-dual-wave-a12661https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Verônica Castro Lima,1,2 Richard B Rosen,1,3 Tiago Santos Prata,2 Syril Dorairaj,4 Leigh Spielberg,1 Mauricio Maia,2 Juliana M Sallum21Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY, 2Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; 3New York Medical College, New York, NY, 4Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USABackground: Several lines of evidence suggest that macular pigment may play a protective role against age-related macular degeneration, but the influence of age on macular pigment density levels remains unclear. This study was designed to investigate the relationship between age and the normal distribution of macular pigment optical density (MPOD) values surrounding the fovea.Methods: Consecutive healthy subjects with no evidence of ocular disease were enrolled in this study. After inclusion, MPOD values were measured at specific eccentricities (0.5, 1, and 2 degrees) from the foveal center using a dual-wavelength autofluorescence method employing a modified confocal scanning laser ophthalmoscope. Whenever both eyes were eligible, one was randomly selected for analysis. The correlation between age and MPOD values was investigated using regression analysis.Results: Thirty subjects (30 eyes) were included (mean age 48.6 ± 16.4 [range 23–77] years). Significant differences were found between MPOD values measured at 0.5, 1, and 2 degrees from the center of the fovea (0.49 ± 0.12 density units, 0.37 ± 0.11 density units, and 0.13 ± 0.05 density units, respectively, P < 0.05). Significant correlations between age and MPOD values at 0.5 and 1 degree were found (P ≤ 0.02). Values measured at 2 degrees did not correlate significantly with age (P = 0.06).Conclusion: In healthy subjects, MPOD values were highest near the foveal center. These values appeared to increase during adulthood (peak at 45–50 years), followed by a gradual reduction after 60 years of age.Keywords: age, macular pigment optical density, dual-wavelength autofluorescence imaging, associationLima VCRosen RBPrata TSDorairaj SSpielberg LMaia MSallum JMDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 685-690 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lima VC Rosen RB Prata TS Dorairaj S Spielberg L Maia M Sallum JM Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
description	Verônica Castro Lima,1,2 Richard B Rosen,1,3 Tiago Santos Prata,2 Syril Dorairaj,4 Leigh Spielberg,1 Mauricio Maia,2 Juliana M Sallum21Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY, 2Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; 3New York Medical College, New York, NY, 4Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USABackground: Several lines of evidence suggest that macular pigment may play a protective role against age-related macular degeneration, but the influence of age on macular pigment density levels remains unclear. This study was designed to investigate the relationship between age and the normal distribution of macular pigment optical density (MPOD) values surrounding the fovea.Methods: Consecutive healthy subjects with no evidence of ocular disease were enrolled in this study. After inclusion, MPOD values were measured at specific eccentricities (0.5, 1, and 2 degrees) from the foveal center using a dual-wavelength autofluorescence method employing a modified confocal scanning laser ophthalmoscope. Whenever both eyes were eligible, one was randomly selected for analysis. The correlation between age and MPOD values was investigated using regression analysis.Results: Thirty subjects (30 eyes) were included (mean age 48.6 ± 16.4 [range 23–77] years). Significant differences were found between MPOD values measured at 0.5, 1, and 2 degrees from the center of the fovea (0.49 ± 0.12 density units, 0.37 ± 0.11 density units, and 0.13 ± 0.05 density units, respectively, P < 0.05). Significant correlations between age and MPOD values at 0.5 and 1 degree were found (P ≤ 0.02). Values measured at 2 degrees did not correlate significantly with age (P = 0.06).Conclusion: In healthy subjects, MPOD values were highest near the foveal center. These values appeared to increase during adulthood (peak at 45–50 years), followed by a gradual reduction after 60 years of age.Keywords: age, macular pigment optical density, dual-wavelength autofluorescence imaging, association
format	article
author	Lima VC Rosen RB Prata TS Dorairaj S Spielberg L Maia M Sallum JM
author_facet	Lima VC Rosen RB Prata TS Dorairaj S Spielberg L Maia M Sallum JM
author_sort	Lima VC
title	Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
title_short	Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
title_full	Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
title_fullStr	Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
title_full_unstemmed	Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
title_sort	association of age and macular pigment optical density using dual-wavelength autofluorescence imaging
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/42ccf806c10546d8be9e124c6d318b44
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Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging

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