Cell-level metadata are indispensable for documenting single-cell sequencing datasets.

Single-cell RNA sequencing (scRNA-seq) provides an unprecedented view of cellular diversity of biological systems. However, across the thousands of publications and datasets generated using this technology, we estimate that only a minority (<25%) of studies provide cell-level metadata information...

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Autores principales:	Sidhant Puntambekar, Jay R Hesselberth, Kent A Riemondy, Rui Fu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/42d096b161074f7ea67e1fd927da2edb
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spelling	oai:doaj.org-article:42d096b161074f7ea67e1fd927da2edb2021-12-02T19:54:27ZCell-level metadata are indispensable for documenting single-cell sequencing datasets.1544-91731545-788510.1371/journal.pbio.3001077https://doaj.org/article/42d096b161074f7ea67e1fd927da2edb2021-05-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001077https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Single-cell RNA sequencing (scRNA-seq) provides an unprecedented view of cellular diversity of biological systems. However, across the thousands of publications and datasets generated using this technology, we estimate that only a minority (<25%) of studies provide cell-level metadata information containing identified cell types and related findings of the published dataset. Metadata omission hinders reproduction, exploration, validation, and knowledge transfer and is a common problem across journals, data repositories, and publication dates. We encourage investigators, reviewers, journals, and data repositories to improve their standards and ensure proper documentation of these valuable datasets.Sidhant PuntambekarJay R HesselberthKent A RiemondyRui FuPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 5, p e3001077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sidhant Puntambekar Jay R Hesselberth Kent A Riemondy Rui Fu Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
description	Single-cell RNA sequencing (scRNA-seq) provides an unprecedented view of cellular diversity of biological systems. However, across the thousands of publications and datasets generated using this technology, we estimate that only a minority (<25%) of studies provide cell-level metadata information containing identified cell types and related findings of the published dataset. Metadata omission hinders reproduction, exploration, validation, and knowledge transfer and is a common problem across journals, data repositories, and publication dates. We encourage investigators, reviewers, journals, and data repositories to improve their standards and ensure proper documentation of these valuable datasets.
format	article
author	Sidhant Puntambekar Jay R Hesselberth Kent A Riemondy Rui Fu
author_facet	Sidhant Puntambekar Jay R Hesselberth Kent A Riemondy Rui Fu
author_sort	Sidhant Puntambekar
title	Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
title_short	Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
title_full	Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
title_fullStr	Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
title_full_unstemmed	Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
title_sort	cell-level metadata are indispensable for documenting single-cell sequencing datasets.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/42d096b161074f7ea67e1fd927da2edb
work_keys_str_mv	AT sidhantpuntambekar celllevelmetadataareindispensablefordocumentingsinglecellsequencingdatasets AT jayrhesselberth celllevelmetadataareindispensablefordocumentingsinglecellsequencingdatasets AT kentariemondy celllevelmetadataareindispensablefordocumentingsinglecellsequencingdatasets AT ruifu celllevelmetadataareindispensablefordocumentingsinglecellsequencingdatasets
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Cell-level metadata are indispensable for documenting single-cell sequencing datasets.

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