New developments in the treatment of osteoarthritis – focus on biologic agents

Jose Ignacio Torrero,1 Carlos Martínez2 1BioTrauma Centre, Escaldes, Principality of Andorra; 2University of Illinois Hospital and Health Sciences System, Chicago, IL, USA Abstract: Osteoarthritis (OA) is one of the most common diseases around the world. Medical, social, and financial co...

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Autores principales:	Torrero JI, Martínez C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/42d743533a7d4b669d716675b5143794
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spelling	oai:doaj.org-article:42d743533a7d4b669d716675b51437942021-12-02T01:28:49ZNew developments in the treatment of osteoarthritis – focus on biologic agents1179-156Xhttps://doaj.org/article/42d743533a7d4b669d716675b51437942015-07-01T00:00:00Zhttp://www.dovepress.com/new-developments-in-the-treatment-of-osteoarthritis-ndash-focus-on-bio-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XJose Ignacio Torrero,1 Carlos Martínez2 1BioTrauma Centre, Escaldes, Principality of Andorra; 2University of Illinois Hospital and Health Sciences System, Chicago, IL, USA Abstract: Osteoarthritis (OA) is one of the most common diseases around the world. Medical, social, and financial consequences oblige clinicians, surgeons, and researchers to focus on finding the best treatment option, to eradicate and stop this degenerative joint disease, in order to avoid surgical options which in many instances are over-indicated. Noninvasive treatments, such as anti-inflammatory drugs, physiotherapy, orthotic devices, dietary supplements, have demonstrated lack of effectiveness. The possibility to perform intra-articular injections with hyaluronic acid, corticosteroids, or the newest but criticized treatment based on platelet-rich plasma (PRP) has changed the management of OA disease. The use of PRP has led to many differences in treatment since there is a lack of consensus about protocols, indications, number of doses, cost-effectiveness, and duration of the treatment. Many publications have suggested efficacy in tendon injuries, but when PRP has been indicated to treat cartilage injuries, things are more inconsistent. Some authors have reported their experience treating OA with PRP, and it seems that, if well indicated, it is an option as a supplementary therapy. Therefore, we need to understand that OA is a mechanical disease which not only produces changes in radiographs, but also affects the quality of life. Pathogenesis of OA has been well explained, providing us new knowledge and future possibilities to improve the clinical approach. From basic science to surgery, there is a great field we all need to contribute to, because the general population is aging and total joint replacements should not be the only solution for OA. So herein is an actual review of the developments for treating OA with biologics, intended to be useful for the population inside orthopedics who could be called bio-orthopedists, since OA is a molecular homeostasis disbalance between catabolism and anabolism triggered by mechanical stress. Keywords: plasma, platelets, interleukines, receptors, orthokineTorrero JIMartínez CDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2015, Iss default, Pp 33-43 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Torrero JI Martínez C New developments in the treatment of osteoarthritis – focus on biologic agents
description	Jose Ignacio Torrero,1 Carlos Martínez2 1BioTrauma Centre, Escaldes, Principality of Andorra; 2University of Illinois Hospital and Health Sciences System, Chicago, IL, USA Abstract: Osteoarthritis (OA) is one of the most common diseases around the world. Medical, social, and financial consequences oblige clinicians, surgeons, and researchers to focus on finding the best treatment option, to eradicate and stop this degenerative joint disease, in order to avoid surgical options which in many instances are over-indicated. Noninvasive treatments, such as anti-inflammatory drugs, physiotherapy, orthotic devices, dietary supplements, have demonstrated lack of effectiveness. The possibility to perform intra-articular injections with hyaluronic acid, corticosteroids, or the newest but criticized treatment based on platelet-rich plasma (PRP) has changed the management of OA disease. The use of PRP has led to many differences in treatment since there is a lack of consensus about protocols, indications, number of doses, cost-effectiveness, and duration of the treatment. Many publications have suggested efficacy in tendon injuries, but when PRP has been indicated to treat cartilage injuries, things are more inconsistent. Some authors have reported their experience treating OA with PRP, and it seems that, if well indicated, it is an option as a supplementary therapy. Therefore, we need to understand that OA is a mechanical disease which not only produces changes in radiographs, but also affects the quality of life. Pathogenesis of OA has been well explained, providing us new knowledge and future possibilities to improve the clinical approach. From basic science to surgery, there is a great field we all need to contribute to, because the general population is aging and total joint replacements should not be the only solution for OA. So herein is an actual review of the developments for treating OA with biologics, intended to be useful for the population inside orthopedics who could be called bio-orthopedists, since OA is a molecular homeostasis disbalance between catabolism and anabolism triggered by mechanical stress. Keywords: plasma, platelets, interleukines, receptors, orthokine
format	article
author	Torrero JI Martínez C
author_facet	Torrero JI Martínez C
author_sort	Torrero JI
title	New developments in the treatment of osteoarthritis – focus on biologic agents
title_short	New developments in the treatment of osteoarthritis – focus on biologic agents
title_full	New developments in the treatment of osteoarthritis – focus on biologic agents
title_fullStr	New developments in the treatment of osteoarthritis – focus on biologic agents
title_full_unstemmed	New developments in the treatment of osteoarthritis – focus on biologic agents
title_sort	new developments in the treatment of osteoarthritis – focus on biologic agents
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/42d743533a7d4b669d716675b5143794
work_keys_str_mv	AT torreroji newdevelopmentsinthetreatmentofosteoarthritisndashfocusonbiologicagents AT martinezc newdevelopmentsinthetreatmentofosteoarthritisndashfocusonbiologicagents
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New developments in the treatment of osteoarthritis &ndash; focus on biologic agents

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New developments in the treatment of osteoarthritis – focus on biologic agents