NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.

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Autores principales: Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco V. Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f
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spelling oai:doaj.org-article:42d7f0f08a7745138e490a7bf976a87f2021-12-02T16:50:35ZNMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-9510.1038/s41467-021-23133-92041-1723https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23133-9https://doaj.org/toc/2041-1723Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.Benjamin CompansCome CamusEmmanouela KallergiSilvia SposiniMagalie MartineauCorey ButlerAdel KechkarRemco V. KlaassenNatacha RetailleauTerrence J. SejnowskiAugust B. SmitJean-Baptiste SibaritaThomas M. BartolDavid PerraisVassiliki NikoletopoulouDaniel ChoquetEric HosyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benjamin Compans
Come Camus
Emmanouela Kallergi
Silvia Sposini
Magalie Martineau
Corey Butler
Adel Kechkar
Remco V. Klaassen
Natacha Retailleau
Terrence J. Sejnowski
August B. Smit
Jean-Baptiste Sibarita
Thomas M. Bartol
David Perrais
Vassiliki Nikoletopoulou
Daniel Choquet
Eric Hosy
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
description Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.
format article
author Benjamin Compans
Come Camus
Emmanouela Kallergi
Silvia Sposini
Magalie Martineau
Corey Butler
Adel Kechkar
Remco V. Klaassen
Natacha Retailleau
Terrence J. Sejnowski
August B. Smit
Jean-Baptiste Sibarita
Thomas M. Bartol
David Perrais
Vassiliki Nikoletopoulou
Daniel Choquet
Eric Hosy
author_facet Benjamin Compans
Come Camus
Emmanouela Kallergi
Silvia Sposini
Magalie Martineau
Corey Butler
Adel Kechkar
Remco V. Klaassen
Natacha Retailleau
Terrence J. Sejnowski
August B. Smit
Jean-Baptiste Sibarita
Thomas M. Bartol
David Perrais
Vassiliki Nikoletopoulou
Daniel Choquet
Eric Hosy
author_sort Benjamin Compans
title NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
title_short NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
title_full NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
title_fullStr NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
title_full_unstemmed NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
title_sort nmdar-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of psd-95
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f
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