NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.
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2021
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oai:doaj.org-article:42d7f0f08a7745138e490a7bf976a87f2021-12-02T16:50:35ZNMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-9510.1038/s41467-021-23133-92041-1723https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23133-9https://doaj.org/toc/2041-1723Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.Benjamin CompansCome CamusEmmanouela KallergiSilvia SposiniMagalie MartineauCorey ButlerAdel KechkarRemco V. KlaassenNatacha RetailleauTerrence J. SejnowskiAugust B. SmitJean-Baptiste SibaritaThomas M. BartolDavid PerraisVassiliki NikoletopoulouDaniel ChoquetEric HosyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Benjamin Compans Come Camus Emmanouela Kallergi Silvia Sposini Magalie Martineau Corey Butler Adel Kechkar Remco V. Klaassen Natacha Retailleau Terrence J. Sejnowski August B. Smit Jean-Baptiste Sibarita Thomas M. Bartol David Perrais Vassiliki Nikoletopoulou Daniel Choquet Eric Hosy NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
description |
Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function. |
format |
article |
author |
Benjamin Compans Come Camus Emmanouela Kallergi Silvia Sposini Magalie Martineau Corey Butler Adel Kechkar Remco V. Klaassen Natacha Retailleau Terrence J. Sejnowski August B. Smit Jean-Baptiste Sibarita Thomas M. Bartol David Perrais Vassiliki Nikoletopoulou Daniel Choquet Eric Hosy |
author_facet |
Benjamin Compans Come Camus Emmanouela Kallergi Silvia Sposini Magalie Martineau Corey Butler Adel Kechkar Remco V. Klaassen Natacha Retailleau Terrence J. Sejnowski August B. Smit Jean-Baptiste Sibarita Thomas M. Bartol David Perrais Vassiliki Nikoletopoulou Daniel Choquet Eric Hosy |
author_sort |
Benjamin Compans |
title |
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
title_short |
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
title_full |
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
title_fullStr |
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
title_full_unstemmed |
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 |
title_sort |
nmdar-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of psd-95 |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f |
work_keys_str_mv |
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