Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells

The multiple myeloma is a malignant clonal tumor of bone marrow plasma cells that is incurable and inevitably recurrent. The mechanisms of progression include tumor cell metastasis, immune escape, resistance to apoptosis, and malignant proliferation. The cysteine-rich secreted acidic protein is clos...

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Autores principales:	Qiqun Pan, Tangfei Li, Zhangqin Luo, Pengji Pan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/42dd0e1ec72440f1a54b75b0b62870df
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spelling	oai:doaj.org-article:42dd0e1ec72440f1a54b75b0b62870df2021-11-08T02:36:02ZExpression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells1741-428810.1155/2021/6101060https://doaj.org/article/42dd0e1ec72440f1a54b75b0b62870df2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6101060https://doaj.org/toc/1741-4288The multiple myeloma is a malignant clonal tumor of bone marrow plasma cells that is incurable and inevitably recurrent. The mechanisms of progression include tumor cell metastasis, immune escape, resistance to apoptosis, and malignant proliferation. The cysteine-rich secreted acidic protein is closely related to the growth, development, remodeling, and repair of cells and tissues. In our study, we divided myeloma patients and patients with other blood diseases into groups and measured the cysteine-rich secreted acidic protein (SPARC) content in the serum of different groups of patients as well as the prognostic differences. The U266 cells were transfected with interfering vectors and overexpressed SPARC vectors to determine the physiological functions of MM cells. Our results showed that SPARC was highly expressed in MM and the survival rate of the high SPARC expression group was lower than that of the low expression group. Interfering SPARC vectors inhibited cancer cell proliferation, migration, and invasion and promoted apoptosis. Overexpression of SPARC vectors promoted cancer cell development. SPARC affected the patient’s disease development by regulating the biological behavior of the MM cells.Qiqun PanTangfei LiZhangqin LuoPengji PanHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Qiqun Pan Tangfei Li Zhangqin Luo Pengji Pan Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
description	The multiple myeloma is a malignant clonal tumor of bone marrow plasma cells that is incurable and inevitably recurrent. The mechanisms of progression include tumor cell metastasis, immune escape, resistance to apoptosis, and malignant proliferation. The cysteine-rich secreted acidic protein is closely related to the growth, development, remodeling, and repair of cells and tissues. In our study, we divided myeloma patients and patients with other blood diseases into groups and measured the cysteine-rich secreted acidic protein (SPARC) content in the serum of different groups of patients as well as the prognostic differences. The U266 cells were transfected with interfering vectors and overexpressed SPARC vectors to determine the physiological functions of MM cells. Our results showed that SPARC was highly expressed in MM and the survival rate of the high SPARC expression group was lower than that of the low expression group. Interfering SPARC vectors inhibited cancer cell proliferation, migration, and invasion and promoted apoptosis. Overexpression of SPARC vectors promoted cancer cell development. SPARC affected the patient’s disease development by regulating the biological behavior of the MM cells.
format	article
author	Qiqun Pan Tangfei Li Zhangqin Luo Pengji Pan
author_facet	Qiqun Pan Tangfei Li Zhangqin Luo Pengji Pan
author_sort	Qiqun Pan
title	Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
title_short	Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
title_full	Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
title_fullStr	Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
title_full_unstemmed	Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells
title_sort	expression of cysteine-rich secreted acidic protein in multiple myeloma and its effect on the biological behavior of cancer cells
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/42dd0e1ec72440f1a54b75b0b62870df
work_keys_str_mv	AT qiqunpan expressionofcysteinerichsecretedacidicproteininmultiplemyelomaanditseffectonthebiologicalbehaviorofcancercells AT tangfeili expressionofcysteinerichsecretedacidicproteininmultiplemyelomaanditseffectonthebiologicalbehaviorofcancercells AT zhangqinluo expressionofcysteinerichsecretedacidicproteininmultiplemyelomaanditseffectonthebiologicalbehaviorofcancercells AT pengjipan expressionofcysteinerichsecretedacidicproteininmultiplemyelomaanditseffectonthebiologicalbehaviorofcancercells
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Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells

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