Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies

Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies

Abstract The undifferentiated state of human induced pluripotent stem cells (hiPSCs) depends on their cell–cell and cell–substrate adhesions. In this study, we report that exposure to botulinum hemagglutinin (HA), an E-cadherin function-blocking agent, selectively removed cells that deviated from th...

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Autores principales: Mee-Hae Kim, Yo Sugawara, Yukako Fujinaga, Masahiro Kino-oka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/42e0863ce2254f54ad5c4b3f516412b7
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