Transgenerational inheritance of impaired larval T cell development in zebrafish

Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Here the authors report that homozygous dnmt1 mutant zebrafish are essentially normal, with the exception of impaired lymphopoiesis, with impaired larval (but not adult) T cell development being transmitte...

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Autores principales:	Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O´Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42e0c083b91b47bbb72a34837b735ceb
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spelling	oai:doaj.org-article:42e0c083b91b47bbb72a34837b735ceb2021-12-02T17:19:41ZTransgenerational inheritance of impaired larval T cell development in zebrafish10.1038/s41467-020-18289-92041-1723https://doaj.org/article/42e0c083b91b47bbb72a34837b735ceb2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18289-9https://doaj.org/toc/2041-1723Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Here the authors report that homozygous dnmt1 mutant zebrafish are essentially normal, with the exception of impaired lymphopoiesis, with impaired larval (but not adult) T cell development being transmitted to subsequent generations by genotypically wildtype fish.Norimasa IwanamiDivine-Fondzenyuy LawirKatarzyna SikoraConnor O´MearaKohei TakeshitaMichael SchorppThomas BoehmNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Norimasa Iwanami Divine-Fondzenyuy Lawir Katarzyna Sikora Connor O´Meara Kohei Takeshita Michael Schorpp Thomas Boehm Transgenerational inheritance of impaired larval T cell development in zebrafish
description	Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Here the authors report that homozygous dnmt1 mutant zebrafish are essentially normal, with the exception of impaired lymphopoiesis, with impaired larval (but not adult) T cell development being transmitted to subsequent generations by genotypically wildtype fish.
format	article
author	Norimasa Iwanami Divine-Fondzenyuy Lawir Katarzyna Sikora Connor O´Meara Kohei Takeshita Michael Schorpp Thomas Boehm
author_facet	Norimasa Iwanami Divine-Fondzenyuy Lawir Katarzyna Sikora Connor O´Meara Kohei Takeshita Michael Schorpp Thomas Boehm
author_sort	Norimasa Iwanami
title	Transgenerational inheritance of impaired larval T cell development in zebrafish
title_short	Transgenerational inheritance of impaired larval T cell development in zebrafish
title_full	Transgenerational inheritance of impaired larval T cell development in zebrafish
title_fullStr	Transgenerational inheritance of impaired larval T cell development in zebrafish
title_full_unstemmed	Transgenerational inheritance of impaired larval T cell development in zebrafish
title_sort	transgenerational inheritance of impaired larval t cell development in zebrafish
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/42e0c083b91b47bbb72a34837b735ceb
work_keys_str_mv	AT norimasaiwanami transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT divinefondzenyuylawir transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT katarzynasikora transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT connoromeara transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT koheitakeshita transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT michaelschorpp transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish AT thomasboehm transgenerationalinheritanceofimpairedlarvaltcelldevelopmentinzebrafish
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Transgenerational inheritance of impaired larval T cell development in zebrafish

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