Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Hepatic lipogenesis is a tightly regulated process, which is elevated in obesity. Here the authors report that FGF15/19, bile acid-induced gut hormones, repress lipogenic genes in the late fed-state by activating small heterodimer partner (SHP) and promoting SHP-dependent recruitment of DNA methyltr...

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Autores principales:	Young-Chae Kim, Sunmi Seok, Yang Zhang, Jian Ma, Bo Kong, Grace Guo, Byron Kemper, Jongsook Kim Kemper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42e5dc3353824fa28751f2c53c9a7584
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id	oai:doaj.org-article:42e5dc3353824fa28751f2c53c9a7584
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spelling	oai:doaj.org-article:42e5dc3353824fa28751f2c53c9a75842021-12-02T10:47:52ZIntestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A10.1038/s41467-020-19803-92041-1723https://doaj.org/article/42e5dc3353824fa28751f2c53c9a75842020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19803-9https://doaj.org/toc/2041-1723Hepatic lipogenesis is a tightly regulated process, which is elevated in obesity. Here the authors report that FGF15/19, bile acid-induced gut hormones, repress lipogenic genes in the late fed-state by activating small heterodimer partner (SHP) and promoting SHP-dependent recruitment of DNA methyltransferase DNMT3A to lipogenic genes.Young-Chae KimSunmi SeokYang ZhangJian MaBo KongGrace GuoByron KemperJongsook Kim KemperNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young-Chae Kim Sunmi Seok Yang Zhang Jian Ma Bo Kong Grace Guo Byron Kemper Jongsook Kim Kemper Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
description	Hepatic lipogenesis is a tightly regulated process, which is elevated in obesity. Here the authors report that FGF15/19, bile acid-induced gut hormones, repress lipogenic genes in the late fed-state by activating small heterodimer partner (SHP) and promoting SHP-dependent recruitment of DNA methyltransferase DNMT3A to lipogenic genes.
format	article
author	Young-Chae Kim Sunmi Seok Yang Zhang Jian Ma Bo Kong Grace Guo Byron Kemper Jongsook Kim Kemper
author_facet	Young-Chae Kim Sunmi Seok Yang Zhang Jian Ma Bo Kong Grace Guo Byron Kemper Jongsook Kim Kemper
author_sort	Young-Chae Kim
title	Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
title_short	Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
title_full	Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
title_fullStr	Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
title_full_unstemmed	Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
title_sort	intestinal fgf15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating shp and dnmt3a
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/42e5dc3353824fa28751f2c53c9a7584
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Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

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