Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function

Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function

Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.

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Autores principales: Chi Zhang, Maria B. Lai, Lavan Khandan, Lindsey A. Lee, Zhe Chen, Harald J. Junge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/42e7520136c84382908bf58215d8f91e
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spelling oai:doaj.org-article:42e7520136c84382908bf58215d8f91e2021-12-02T17:06:26ZNorrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function10.1038/ncomms160502041-1723https://doaj.org/article/42e7520136c84382908bf58215d8f91e2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16050https://doaj.org/toc/2041-1723Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.Chi ZhangMaria B. LaiLavan KhandanLindsey A. LeeZhe ChenHarald J. JungeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chi Zhang
Maria B. Lai
Lavan Khandan
Lindsey A. Lee
Zhe Chen
Harald J. Junge
Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
description Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.
format article
author Chi Zhang
Maria B. Lai
Lavan Khandan
Lindsey A. Lee
Zhe Chen
Harald J. Junge
author_facet Chi Zhang
Maria B. Lai
Lavan Khandan
Lindsey A. Lee
Zhe Chen
Harald J. Junge
author_sort Chi Zhang
title Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
title_short Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
title_full Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
title_fullStr Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
title_full_unstemmed Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
title_sort norrin-induced frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/42e7520136c84382908bf58215d8f91e
work_keys_str_mv AT chizhang norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
AT mariablai norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
AT lavankhandan norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
AT lindseyalee norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
AT zhechen norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
AT haraldjjunge norrininducedfrizzled4endocytosisandendolysosomaltraffickingcontrolretinalangiogenesisandbarrierfunction
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