High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine

Abstract This study reports the high-yield production of a novel 133/135La theranostic pair at a 22 MeV proton beam energy as an attractive alternative to the recently introduced 132/135La pair, demonstrating over an order of magnitude production increase of 133/135La (231 ± 8 MBq 133La and 166 ± 5 ...

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Autores principales:	Bryce J. B. Nelson, John Wilson, Jan D. Andersson, Frank Wuest
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42e79a290ecb463ba1b84d8e8a9ae179
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spelling	oai:doaj.org-article:42e79a290ecb463ba1b84d8e8a9ae1792021-12-02T12:42:19ZHigh yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine10.1038/s41598-020-79198-x2045-2322https://doaj.org/article/42e79a290ecb463ba1b84d8e8a9ae1792020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79198-xhttps://doaj.org/toc/2045-2322Abstract This study reports the high-yield production of a novel 133/135La theranostic pair at a 22 MeV proton beam energy as an attractive alternative to the recently introduced 132/135La pair, demonstrating over an order of magnitude production increase of 133/135La (231 ± 8 MBq 133La and 166 ± 5 MBq 135La at End of Bombardment (EOB)) compared to 11.9 MeV production of 132/135La (0.82 ± 0.06 MBq 132La and 19.0 ± 1.2 MBq 135La) for 500 µA·min irradiations. A new sealed solid cyclotron target is introduced, which is fast to assemble, easy to handle, storable, and contains reusable components. Radiolabeling with macrocyclic chelators DOTA and macropa achieved full incorporation, with respective apparent 133La molar activites of 33 ± 5 GBq/µmol and 30 ± 4 GBq/µmol. PET centers with access to a 22 MeV capable cyclotron could produce clinically-relevant doses of 133/135La, via natBa irradiation, as a standalone theranostic agent for PET imaging and Auger electron therapy. With lower positron energies and less energetic and abundant gamma rays than 68Ga, 44Sc and 132La, 133La appears to be an attractive radiometal candidate for PET applications requiring a higher scanning resolution, a relatively long isotopic half-life, ease of handling, and a low patient dose.Bryce J. B. NelsonJohn WilsonJan D. AnderssonFrank WuestNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryce J. B. Nelson John Wilson Jan D. Andersson Frank Wuest High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
description	Abstract This study reports the high-yield production of a novel 133/135La theranostic pair at a 22 MeV proton beam energy as an attractive alternative to the recently introduced 132/135La pair, demonstrating over an order of magnitude production increase of 133/135La (231 ± 8 MBq 133La and 166 ± 5 MBq 135La at End of Bombardment (EOB)) compared to 11.9 MeV production of 132/135La (0.82 ± 0.06 MBq 132La and 19.0 ± 1.2 MBq 135La) for 500 µA·min irradiations. A new sealed solid cyclotron target is introduced, which is fast to assemble, easy to handle, storable, and contains reusable components. Radiolabeling with macrocyclic chelators DOTA and macropa achieved full incorporation, with respective apparent 133La molar activites of 33 ± 5 GBq/µmol and 30 ± 4 GBq/µmol. PET centers with access to a 22 MeV capable cyclotron could produce clinically-relevant doses of 133/135La, via natBa irradiation, as a standalone theranostic agent for PET imaging and Auger electron therapy. With lower positron energies and less energetic and abundant gamma rays than 68Ga, 44Sc and 132La, 133La appears to be an attractive radiometal candidate for PET applications requiring a higher scanning resolution, a relatively long isotopic half-life, ease of handling, and a low patient dose.
format	article
author	Bryce J. B. Nelson John Wilson Jan D. Andersson Frank Wuest
author_facet	Bryce J. B. Nelson John Wilson Jan D. Andersson Frank Wuest
author_sort	Bryce J. B. Nelson
title	High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
title_short	High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
title_full	High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
title_fullStr	High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
title_full_unstemmed	High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine
title_sort	high yield cyclotron production of a novel 133/135la theranostic pair for nuclear medicine
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/42e79a290ecb463ba1b84d8e8a9ae179
work_keys_str_mv	AT brycejbnelson highyieldcyclotronproductionofanovel133135latheranosticpairfornuclearmedicine AT johnwilson highyieldcyclotronproductionofanovel133135latheranosticpairfornuclearmedicine AT jandandersson highyieldcyclotronproductionofanovel133135latheranosticpairfornuclearmedicine AT frankwuest highyieldcyclotronproductionofanovel133135latheranosticpairfornuclearmedicine
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High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine

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