Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease

Abstract Chronic kidney disease (CKD) is a major public health burden around the world. The gut microbiome may contribute to CKD progression and serve as a promising therapeutic target. Colonic dialysis has long been used in China to help remove gut-derived toxins to delay CKD progression. Since dis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yueming Li, Minhui Dai, Jianqin Yan, Fang Liu, Xi Wang, Lizhen Lin, Mei Huang, Cuifang Li, Rui Wen, Jiao Qin, Hui Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42ea6622e8934583acd64a718be5da74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:42ea6622e8934583acd64a718be5da74
record_format	dspace
spelling	oai:doaj.org-article:42ea6622e8934583acd64a718be5da742021-12-02T17:22:57ZColonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease10.1038/s41598-021-91722-12045-2322https://doaj.org/article/42ea6622e8934583acd64a718be5da742021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91722-1https://doaj.org/toc/2045-2322Abstract Chronic kidney disease (CKD) is a major public health burden around the world. The gut microbiome may contribute to CKD progression and serve as a promising therapeutic target. Colonic dialysis has long been used in China to help remove gut-derived toxins to delay CKD progression. Since disturbances in the gut biome may influence disease progression, we wondered whether colonic dialysis may mitigate the condition by influencing the biome. We compared the gut microbiota, based on 16S rRNA gene sequencing, in fecal samples of 25 patients with CKD (stages 3–5) who were receiving colonic dialysis(group CD), 25 outpatients with CKD not receiving colonic dialysis(group OP), and 34 healthy subjects(group HS). Richness of gut microbiota was similar between patients on colonic dialysis and healthy subjects, and richness in these two groups was significantly higher than that in patients not on colonic dialysis. Colonic dialysis also altered the profile of microbes in the gut of CKD patients, bringing it closer to the profile in healthy subjects. Colonic dialysis may protect renal function in pre-dialysis CKD by mitigating dysbiosis of gut microbiota.Yueming LiMinhui DaiJianqin YanFang LiuXi WangLizhen LinMei HuangCuifang LiRui WenJiao QinHui XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yueming Li Minhui Dai Jianqin Yan Fang Liu Xi Wang Lizhen Lin Mei Huang Cuifang Li Rui Wen Jiao Qin Hui Xu Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
description	Abstract Chronic kidney disease (CKD) is a major public health burden around the world. The gut microbiome may contribute to CKD progression and serve as a promising therapeutic target. Colonic dialysis has long been used in China to help remove gut-derived toxins to delay CKD progression. Since disturbances in the gut biome may influence disease progression, we wondered whether colonic dialysis may mitigate the condition by influencing the biome. We compared the gut microbiota, based on 16S rRNA gene sequencing, in fecal samples of 25 patients with CKD (stages 3–5) who were receiving colonic dialysis(group CD), 25 outpatients with CKD not receiving colonic dialysis(group OP), and 34 healthy subjects(group HS). Richness of gut microbiota was similar between patients on colonic dialysis and healthy subjects, and richness in these two groups was significantly higher than that in patients not on colonic dialysis. Colonic dialysis also altered the profile of microbes in the gut of CKD patients, bringing it closer to the profile in healthy subjects. Colonic dialysis may protect renal function in pre-dialysis CKD by mitigating dysbiosis of gut microbiota.
format	article
author	Yueming Li Minhui Dai Jianqin Yan Fang Liu Xi Wang Lizhen Lin Mei Huang Cuifang Li Rui Wen Jiao Qin Hui Xu
author_facet	Yueming Li Minhui Dai Jianqin Yan Fang Liu Xi Wang Lizhen Lin Mei Huang Cuifang Li Rui Wen Jiao Qin Hui Xu
author_sort	Yueming Li
title	Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
title_short	Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
title_full	Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
title_fullStr	Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
title_full_unstemmed	Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
title_sort	colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42ea6622e8934583acd64a718be5da74
work_keys_str_mv	AT yuemingli colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT minhuidai colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT jianqinyan colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT fangliu colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT xiwang colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT lizhenlin colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT meihuang colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT cuifangli colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT ruiwen colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT jiaoqin colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease AT huixu colonicdialysiscaninfluencegutfloratoprotectrenalfunctioninpatientswithpredialysischronickidneydisease
_version_	1718380963425157120

Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease

Ejemplares similares