Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.

<h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to popul...

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Autores principales:	Young Eun Chon, Eun Hee Choi, Ki Jun Song, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Chae Yoon Chon, Sang Hoon Ahn, Seung Up Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42eddf83a650488c9ee117125e2aabcc
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spelling	oai:doaj.org-article:42eddf83a650488c9ee117125e2aabcc2021-11-18T08:14:14ZPerformance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.1932-620310.1371/journal.pone.0044930https://doaj.org/article/42eddf83a650488c9ee117125e2aabcc2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049764/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB.<h4>Methods</h4>Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study.<h4>Result</h4>A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%.<h4>Conclusion</h4>TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.Young Eun ChonEun Hee ChoiKi Jun SongJun Yong ParkDo Young KimKwang-Hyub HanChae Yoon ChonSang Hoon AhnSeung Up KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e44930 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
description	<h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB.<h4>Methods</h4>Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study.<h4>Result</h4>A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%.<h4>Conclusion</h4>TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.
format	article
author	Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim
author_facet	Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim
author_sort	Young Eun Chon
title	Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
title_short	Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
title_full	Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
title_fullStr	Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
title_full_unstemmed	Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
title_sort	performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis b: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/42eddf83a650488c9ee117125e2aabcc
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Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.

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