Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.
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Nature Portfolio
2017
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oai:doaj.org-article:42f1fba27d344814905048b4a4333e892021-12-02T14:42:24ZCancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression10.1038/ncomms143992041-1723https://doaj.org/article/42f1fba27d344814905048b4a4333e892017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14399https://doaj.org/toc/2041-1723Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.Wen Wen XuBin LiXin Yuan GuanSookja K. ChungYang WangYim Ling YipSimon Y. K. LawKin Tak ChanNikki P. Y. LeeKwok Wah ChanLi Yan XuEn Min LiSai Wah TsaoQing-Yu HeAnnie L. M. CheungNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| description |
Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases. |
| format |
article |
| author |
Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung |
| author_facet |
Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung |
| author_sort |
Wen Wen Xu |
| title |
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| title_short |
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| title_full |
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| title_fullStr |
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| title_full_unstemmed |
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| title_sort |
cancer cell-secreted igf2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/42f1fba27d344814905048b4a4333e89 |
| work_keys_str_mv |
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