SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes

Cellular senescence: SMARCD1, a key molecule in lipid accumulation A team led by Yoshinori Katakura at Kyushu University tried to clarify the molecular mechanisms of pathogenesis of fatty liver, focused on SMARCD1, one of the identified senescence-associated genes, and revealed its pivotal roles in...

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Autores principales:	Chisato Inoue, Chong Zhao, Yumi Tsuduki, Miyako Udono, Lixiang Wang, Masatoshi Nomura, Yoshinori Katakura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/42f29cf05d51441cb928ed551febcc74
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spelling	oai:doaj.org-article:42f29cf05d51441cb928ed551febcc742021-12-02T14:22:13ZSMARCD1 regulates senescence-associated lipid accumulation in hepatocytes10.1038/s41514-017-0011-12056-3973https://doaj.org/article/42f29cf05d51441cb928ed551febcc742017-08-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0011-1https://doaj.org/toc/2056-3973Cellular senescence: SMARCD1, a key molecule in lipid accumulation A team led by Yoshinori Katakura at Kyushu University tried to clarify the molecular mechanisms of pathogenesis of fatty liver, focused on SMARCD1, one of the identified senescence-associated genes, and revealed its pivotal roles in cellular senescence induction and lipid accumulation in hepatocytes. SMARCD1 is a member of the SWI/SNF chromatin remodeling complex family and known to regulate the transcription of target genes through the alteration of chromatin structure. The results obtained here suggest that dietary imbalance such as high-fat diet impaires expression of SMARCD1, which triggers cellular senescence and lipid accumulation in hepatocytes, indicating a potential role of SMARCD1 in the prevention of lifestyle-related diseases.Chisato InoueChong ZhaoYumi TsudukiMiyako UdonoLixiang WangMasatoshi NomuraYoshinori KatakuraNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Chisato Inoue Chong Zhao Yumi Tsuduki Miyako Udono Lixiang Wang Masatoshi Nomura Yoshinori Katakura SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
description	Cellular senescence: SMARCD1, a key molecule in lipid accumulation A team led by Yoshinori Katakura at Kyushu University tried to clarify the molecular mechanisms of pathogenesis of fatty liver, focused on SMARCD1, one of the identified senescence-associated genes, and revealed its pivotal roles in cellular senescence induction and lipid accumulation in hepatocytes. SMARCD1 is a member of the SWI/SNF chromatin remodeling complex family and known to regulate the transcription of target genes through the alteration of chromatin structure. The results obtained here suggest that dietary imbalance such as high-fat diet impaires expression of SMARCD1, which triggers cellular senescence and lipid accumulation in hepatocytes, indicating a potential role of SMARCD1 in the prevention of lifestyle-related diseases.
format	article
author	Chisato Inoue Chong Zhao Yumi Tsuduki Miyako Udono Lixiang Wang Masatoshi Nomura Yoshinori Katakura
author_facet	Chisato Inoue Chong Zhao Yumi Tsuduki Miyako Udono Lixiang Wang Masatoshi Nomura Yoshinori Katakura
author_sort	Chisato Inoue
title	SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
title_short	SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
title_full	SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
title_fullStr	SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
title_full_unstemmed	SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
title_sort	smarcd1 regulates senescence-associated lipid accumulation in hepatocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/42f29cf05d51441cb928ed551febcc74
work_keys_str_mv	AT chisatoinoue smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT chongzhao smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT yumitsuduki smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT miyakoudono smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT lixiangwang smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT masatoshinomura smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes AT yoshinorikatakura smarcd1regulatessenescenceassociatedlipidaccumulationinhepatocytes
_version_	1718391482135609344

SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes

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