Biocompatible nanocomposite for PET/MRI hybrid imaging

Erica Locatelli,1 Larraitz Gil,2 Liron Limor Israel,3 Lorena Passoni,4,5 Maria Naddaka,1 Andrea Pucci,1 Torsten Reese,6 Vanessa Gomez-Vallejo,2 Paolo Milani,5,7 Michela Matteoli,4,8 Jordi Llop,2 Jean Paul Lellouche,3 Mauro Comes Franchini11Department of Industrial Chemistry &ldquo;Toso Monta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Locatelli E, Gil L, Israel LL, Passoni L, Naddaka M, Pucci A, Reese T, Gomez-Vallejo V, Milani P, Matteoli M, Llop J, Lellouche JP, Comes Franchini M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/42f406c7c394462a8cc054a919500571
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:42f406c7c394462a8cc054a919500571
record_format	dspace
spelling	oai:doaj.org-article:42f406c7c394462a8cc054a9195005712021-12-02T05:55:47ZBiocompatible nanocomposite for PET/MRI hybrid imaging1176-91141178-2013https://doaj.org/article/42f406c7c394462a8cc054a9195005712012-12-01T00:00:00Zhttp://www.dovepress.com/biocompatible-nanocomposite-for-petmri-hybrid-imaging-a11733https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Erica Locatelli,1 Larraitz Gil,2 Liron Limor Israel,3 Lorena Passoni,4,5 Maria Naddaka,1 Andrea Pucci,1 Torsten Reese,6 Vanessa Gomez-Vallejo,2 Paolo Milani,5,7 Michela Matteoli,4,8 Jordi Llop,2 Jean Paul Lellouche,3 Mauro Comes Franchini11Department of Industrial Chemistry &ldquo;Toso Montanari&rdquo;. University of Bologna, Italy; 2Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebasti&aacute;n, Guip&uacute;zcoa, Spain; 3Department of Chemistry, Nanomaterials Research Centre, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 4Department of Medical Biotechnology and Translational Medicine, University of Milano, Italy; 5Fondazione Filarete, Milano, Italy; 6Imaging Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebasti&aacute;n, Guip&uacute;zcoa, Spain; 7CIMAINA and Department of Physics, University of Milano, Italy; 8Humanitas Clinical and Research Center, Rozzano, ItalyAbstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2&#39;-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.Keywords: maghemite nanoparticles, organic coating, polymeric nanoparticles, magnetic resonance imaging, radiolabeling, positron emission tomographyLocatelli EGil LIsrael LLPassoni LNaddaka MPucci AReese TGomez-Vallejo VMilani PMatteoli MLlop JLellouche JPComes Franchini MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 6021-6033 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Locatelli E Gil L Israel LL Passoni L Naddaka M Pucci A Reese T Gomez-Vallejo V Milani P Matteoli M Llop J Lellouche JP Comes Franchini M Biocompatible nanocomposite for PET/MRI hybrid imaging
description	Erica Locatelli,1 Larraitz Gil,2 Liron Limor Israel,3 Lorena Passoni,4,5 Maria Naddaka,1 Andrea Pucci,1 Torsten Reese,6 Vanessa Gomez-Vallejo,2 Paolo Milani,5,7 Michela Matteoli,4,8 Jordi Llop,2 Jean Paul Lellouche,3 Mauro Comes Franchini11Department of Industrial Chemistry &ldquo;Toso Montanari&rdquo;. University of Bologna, Italy; 2Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebasti&aacute;n, Guip&uacute;zcoa, Spain; 3Department of Chemistry, Nanomaterials Research Centre, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 4Department of Medical Biotechnology and Translational Medicine, University of Milano, Italy; 5Fondazione Filarete, Milano, Italy; 6Imaging Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebasti&aacute;n, Guip&uacute;zcoa, Spain; 7CIMAINA and Department of Physics, University of Milano, Italy; 8Humanitas Clinical and Research Center, Rozzano, ItalyAbstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2&#39;-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.Keywords: maghemite nanoparticles, organic coating, polymeric nanoparticles, magnetic resonance imaging, radiolabeling, positron emission tomography
format	article
author	Locatelli E Gil L Israel LL Passoni L Naddaka M Pucci A Reese T Gomez-Vallejo V Milani P Matteoli M Llop J Lellouche JP Comes Franchini M
author_facet	Locatelli E Gil L Israel LL Passoni L Naddaka M Pucci A Reese T Gomez-Vallejo V Milani P Matteoli M Llop J Lellouche JP Comes Franchini M
author_sort	Locatelli E
title	Biocompatible nanocomposite for PET/MRI hybrid imaging
title_short	Biocompatible nanocomposite for PET/MRI hybrid imaging
title_full	Biocompatible nanocomposite for PET/MRI hybrid imaging
title_fullStr	Biocompatible nanocomposite for PET/MRI hybrid imaging
title_full_unstemmed	Biocompatible nanocomposite for PET/MRI hybrid imaging
title_sort	biocompatible nanocomposite for pet/mri hybrid imaging
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/42f406c7c394462a8cc054a919500571
work_keys_str_mv	AT locatellie biocompatiblenanocompositeforpetmrihybridimaging AT gill biocompatiblenanocompositeforpetmrihybridimaging AT israelll biocompatiblenanocompositeforpetmrihybridimaging AT passonil biocompatiblenanocompositeforpetmrihybridimaging AT naddakam biocompatiblenanocompositeforpetmrihybridimaging AT puccia biocompatiblenanocompositeforpetmrihybridimaging AT reeset biocompatiblenanocompositeforpetmrihybridimaging AT gomezvallejov biocompatiblenanocompositeforpetmrihybridimaging AT milanip biocompatiblenanocompositeforpetmrihybridimaging AT matteolim biocompatiblenanocompositeforpetmrihybridimaging AT llopj biocompatiblenanocompositeforpetmrihybridimaging AT lellouchejp biocompatiblenanocompositeforpetmrihybridimaging AT comesfranchinim biocompatiblenanocompositeforpetmrihybridimaging
_version_	1718400167236861952

Biocompatible nanocomposite for PET/MRI hybrid imaging

Ejemplares similares