Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice

Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn ext...

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Autores principales:	Huiwon No, Sang Hyun Nam, Hee Won Seo, JeongHyeon Seo, Soo-Hyun Park, Set-Byeol Kim, Jun-Sub Jung, Jongyeol Park, Jaekeun Choi, Jae-Yong Lee, Hong-Won Suh, Soon Sung Lim, Jin-Kyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	atopic dermatitis 2,4-dinitrochlorobenzene purple corn ige Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/42f43ff4dba646da9d37fc3f381df544
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spelling	oai:doaj.org-article:42f43ff4dba646da9d37fc3f381df5442021-11-04T15:00:42ZPurple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice1976-83542151-248510.1080/19768354.2021.1974938https://doaj.org/article/42f43ff4dba646da9d37fc3f381df5442021-09-01T00:00:00Zhttp://dx.doi.org/10.1080/19768354.2021.1974938https://doaj.org/toc/1976-8354https://doaj.org/toc/2151-2485Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn extract, FB801, might have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and challenge (0.3%) by DNCB were performed on the dorsal skin and right ear of BALB/c mice to induce AD. Following FB801 and dexamethasone administered orally, the severity of skin lesions was examined macroscopically and histologically. Serum levels of immunoglobulin E (IgE) and various cytokines were determined by enzyme-linked immunosorbent assay. Oral administration of FB801 significantly reduced typical symptoms of AD (erythema/bleeding, swelling, molting/erosion and scaling/drying), scratching frequencies, and the recruitment of inflammatory and mast cells. In addition, FB801 suppressed serum levels of IgE and T helper (Th)2 type cytokines such as interleukin (IL)-4 and IL-10 in DNCB-treated BALB/c mice. Furthermore, FB801 reduced the degradation of inhibitor of nuclear factor-κB proteins (NF-κB) in tumor necrosis factor (TNF)-α-stimulated human keratinocyte (HaCaT) cells. These results suggest that FB801 inhibited the development of the AD-like skin symptoms by regulating Th1 and Th2 responses in the skin lesions in mice and suppressing TNF-α induced NF-κB activation in HaCaT cells, suggesting that FB801 has potential application as an effective alternative therapy for the prevention and management of AD.Huiwon NoSang Hyun NamHee Won SeoJeongHyeon SeoSoo-Hyun ParkSet-Byeol KimJun-Sub JungJongyeol ParkJaekeun ChoiJae-Yong LeeHong-Won SuhSoon Sung LimJin-Kyung KimTaylor & Francis Grouparticleatopic dermatitis2,4-dinitrochlorobenzenepurple cornigeMedicine (General)R5-920Biology (General)QH301-705.5ENAnimal Cells and Systems, Vol 25, Iss 5, Pp 272-282 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis 2,4-dinitrochlorobenzene purple corn ige Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	atopic dermatitis 2,4-dinitrochlorobenzene purple corn ige Medicine (General) R5-920 Biology (General) QH301-705.5 Huiwon No Sang Hyun Nam Hee Won Seo JeongHyeon Seo Soo-Hyun Park Set-Byeol Kim Jun-Sub Jung Jongyeol Park Jaekeun Choi Jae-Yong Lee Hong-Won Suh Soon Sung Lim Jin-Kyung Kim Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
description	Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn extract, FB801, might have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and challenge (0.3%) by DNCB were performed on the dorsal skin and right ear of BALB/c mice to induce AD. Following FB801 and dexamethasone administered orally, the severity of skin lesions was examined macroscopically and histologically. Serum levels of immunoglobulin E (IgE) and various cytokines were determined by enzyme-linked immunosorbent assay. Oral administration of FB801 significantly reduced typical symptoms of AD (erythema/bleeding, swelling, molting/erosion and scaling/drying), scratching frequencies, and the recruitment of inflammatory and mast cells. In addition, FB801 suppressed serum levels of IgE and T helper (Th)2 type cytokines such as interleukin (IL)-4 and IL-10 in DNCB-treated BALB/c mice. Furthermore, FB801 reduced the degradation of inhibitor of nuclear factor-κB proteins (NF-κB) in tumor necrosis factor (TNF)-α-stimulated human keratinocyte (HaCaT) cells. These results suggest that FB801 inhibited the development of the AD-like skin symptoms by regulating Th1 and Th2 responses in the skin lesions in mice and suppressing TNF-α induced NF-κB activation in HaCaT cells, suggesting that FB801 has potential application as an effective alternative therapy for the prevention and management of AD.
format	article
author	Huiwon No Sang Hyun Nam Hee Won Seo JeongHyeon Seo Soo-Hyun Park Set-Byeol Kim Jun-Sub Jung Jongyeol Park Jaekeun Choi Jae-Yong Lee Hong-Won Suh Soon Sung Lim Jin-Kyung Kim
author_facet	Huiwon No Sang Hyun Nam Hee Won Seo JeongHyeon Seo Soo-Hyun Park Set-Byeol Kim Jun-Sub Jung Jongyeol Park Jaekeun Choi Jae-Yong Lee Hong-Won Suh Soon Sung Lim Jin-Kyung Kim
author_sort	Huiwon No
title	Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
title_short	Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
title_full	Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
title_fullStr	Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
title_full_unstemmed	Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice
title_sort	purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in balb/c mice
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/42f43ff4dba646da9d37fc3f381df544
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Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice

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