Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system

The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity.

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Autores principales:	Yihan Zhang, Wei Qin, Xiaochan Lu, Jason Xu, Haigen Huang, Haipeng Bai, Song Li, Shuo Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4304a735608a492eac54379a55d10def
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spelling	oai:doaj.org-article:4304a735608a492eac54379a55d10def2021-12-02T10:47:59ZProgrammable base editing of zebrafish genome using a modified CRISPR-Cas9 system10.1038/s41467-017-00175-62041-1723https://doaj.org/article/4304a735608a492eac54379a55d10def2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00175-6https://doaj.org/toc/2041-1723The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity.Yihan ZhangWei QinXiaochan LuJason XuHaigen HuangHaipeng BaiSong LiShuo LinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yihan Zhang Wei Qin Xiaochan Lu Jason Xu Haigen Huang Haipeng Bai Song Li Shuo Lin Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
description	The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity.
format	article
author	Yihan Zhang Wei Qin Xiaochan Lu Jason Xu Haigen Huang Haipeng Bai Song Li Shuo Lin
author_facet	Yihan Zhang Wei Qin Xiaochan Lu Jason Xu Haigen Huang Haipeng Bai Song Li Shuo Lin
author_sort	Yihan Zhang
title	Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
title_short	Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
title_full	Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
title_fullStr	Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
title_full_unstemmed	Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
title_sort	programmable base editing of zebrafish genome using a modified crispr-cas9 system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4304a735608a492eac54379a55d10def
work_keys_str_mv	AT yihanzhang programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT weiqin programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT xiaochanlu programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT jasonxu programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT haigenhuang programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT haipengbai programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT songli programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system AT shuolin programmablebaseeditingofzebrafishgenomeusingamodifiedcrisprcas9system
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Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system

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