Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.

<h4>Objectives</h4>Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unk...

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Autores principales:	Ryota Sato, Keitaro Akita, Takenori Ikoma, Keisuke Iguchi, Takayo Murase, Takashi Nakamura, Seigo Akari, Satoshi Mogi, Yoshihisa Naruse, Hayato Ohtani, Yuichiro Maekawa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4306ee9c591e4303b03fe8eb50ad33ec
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spelling	oai:doaj.org-article:4306ee9c591e4303b03fe8eb50ad33ec2021-12-02T20:08:15ZAssociation between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.1932-620310.1371/journal.pone.0257227https://doaj.org/article/4306ee9c591e4303b03fe8eb50ad33ec2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257227https://doaj.org/toc/1932-6203<h4>Objectives</h4>Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown.<h4>Methods</h4>Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated.<h4>Results</h4>We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events.<h4>Conclusions</h4>A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.Ryota SatoKeitaro AkitaTakenori IkomaKeisuke IguchiTakayo MuraseTakashi NakamuraSeigo AkariSatoshi MogiYoshihisa NaruseHayato OhtaniYuichiro MaekawaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257227 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryota Sato Keitaro Akita Takenori Ikoma Keisuke Iguchi Takayo Murase Takashi Nakamura Seigo Akari Satoshi Mogi Yoshihisa Naruse Hayato Ohtani Yuichiro Maekawa Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
description	<h4>Objectives</h4>Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown.<h4>Methods</h4>Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated.<h4>Results</h4>We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events.<h4>Conclusions</h4>A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.
format	article
author	Ryota Sato Keitaro Akita Takenori Ikoma Keisuke Iguchi Takayo Murase Takashi Nakamura Seigo Akari Satoshi Mogi Yoshihisa Naruse Hayato Ohtani Yuichiro Maekawa
author_facet	Ryota Sato Keitaro Akita Takenori Ikoma Keisuke Iguchi Takayo Murase Takashi Nakamura Seigo Akari Satoshi Mogi Yoshihisa Naruse Hayato Ohtani Yuichiro Maekawa
author_sort	Ryota Sato
title	Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
title_short	Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
title_full	Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
title_fullStr	Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
title_full_unstemmed	Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
title_sort	association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4306ee9c591e4303b03fe8eb50ad33ec
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Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.

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