Determinants Of Plasma Homocysteine Levels In Healthy People

Elevated plasma homocysteine is considered to be an independent risk factor forcardiovascular diseases. In the present study, relations between plasma homocysteineand demographics, lifestyle factors and blood vitamin concentrations wereinvestigated in a population-based sample. Homocysteine and vita...

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Autores principales:	Ş. Nur Aksoy, İclal Geyikli, E. İlker Saygılı
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2006
Materias:	Homocysteine sex age smoking fruit vegetable folate B12 body mass index Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/43105e7f659f4ec39145ca897cbecba9
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spelling	oai:doaj.org-article:43105e7f659f4ec39145ca897cbecba92021-12-02T16:12:48ZDeterminants Of Plasma Homocysteine Levels In Healthy People0250-46851303-829Xhttps://doaj.org/article/43105e7f659f4ec39145ca897cbecba92006-12-01T00:00:00Zhttp://www.turkjbiochem.com/2006/175.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XElevated plasma homocysteine is considered to be an independent risk factor forcardiovascular diseases. In the present study, relations between plasma homocysteineand demographics, lifestyle factors and blood vitamin concentrations wereinvestigated in a population-based sample. Homocysteine and vitamin concentrationswere measured in the 126 healthy people aged 31-73 year. All participantscompleted the questionnaires about factors including demographics and lifestylefactors, and dietary records. Homocysteine values were higher in men as comparedto women (11.8 vs. 10.6 μmol/L; p <0.05). Non-smokers had lower homocysteinelevels as compared to light-moderate smokers (10.0 vs. 11.1 μmol/L; p <0.05) and ascompared to heavy smokers (10.0 vs. 12.2 μmol/L; p <0.01). Homocysteine was significantlylower in the highest fruit and vegetable intake group than in the lowest intakegroup (10.4 vs. 12.8; p <0.01). The homocysteine concentration was negativelyassociated with serum folate (r = -0.39, p <0.0001) and serum vitamin B12 (r = -0.25,p <0.005), and was positively associated with age (r = 0.029; p <0.001). There wasalso a weak correlation between body mass index and homocysteine. Multivariateanalysis after adjusting for several potential confounders confirmed the previousassociations. No association was found between homocysteine levels and physicalstatus or blood lipids. Homocysteine levels were not also associated with educationor the financial status of the participants. In conclusion, in this healthy group, thesignificant predictors of homocysteine concentration were sex, age, smoking, fruitand vegetable intake, body mass index, serum folate, and serum vitamin B12.Ş. Nur Aksoyİclal Geyikli,E. İlker SaygılıDe GruyterarticleHomocysteinesexagesmokingfruitvegetablefolateB12body mass indexBiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 31, Iss 4, Pp 175-181 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Homocysteine sex age smoking fruit vegetable folate B12 body mass index Biochemistry QD415-436
spellingShingle	Homocysteine sex age smoking fruit vegetable folate B12 body mass index Biochemistry QD415-436 Ş. Nur Aksoy İclal Geyikli, E. İlker Saygılı Determinants Of Plasma Homocysteine Levels In Healthy People
description	Elevated plasma homocysteine is considered to be an independent risk factor forcardiovascular diseases. In the present study, relations between plasma homocysteineand demographics, lifestyle factors and blood vitamin concentrations wereinvestigated in a population-based sample. Homocysteine and vitamin concentrationswere measured in the 126 healthy people aged 31-73 year. All participantscompleted the questionnaires about factors including demographics and lifestylefactors, and dietary records. Homocysteine values were higher in men as comparedto women (11.8 vs. 10.6 μmol/L; p <0.05). Non-smokers had lower homocysteinelevels as compared to light-moderate smokers (10.0 vs. 11.1 μmol/L; p <0.05) and ascompared to heavy smokers (10.0 vs. 12.2 μmol/L; p <0.01). Homocysteine was significantlylower in the highest fruit and vegetable intake group than in the lowest intakegroup (10.4 vs. 12.8; p <0.01). The homocysteine concentration was negativelyassociated with serum folate (r = -0.39, p <0.0001) and serum vitamin B12 (r = -0.25,p <0.005), and was positively associated with age (r = 0.029; p <0.001). There wasalso a weak correlation between body mass index and homocysteine. Multivariateanalysis after adjusting for several potential confounders confirmed the previousassociations. No association was found between homocysteine levels and physicalstatus or blood lipids. Homocysteine levels were not also associated with educationor the financial status of the participants. In conclusion, in this healthy group, thesignificant predictors of homocysteine concentration were sex, age, smoking, fruitand vegetable intake, body mass index, serum folate, and serum vitamin B12.
format	article
author	Ş. Nur Aksoy İclal Geyikli, E. İlker Saygılı
author_facet	Ş. Nur Aksoy İclal Geyikli, E. İlker Saygılı
author_sort	Ş. Nur Aksoy
title	Determinants Of Plasma Homocysteine Levels In Healthy People
title_short	Determinants Of Plasma Homocysteine Levels In Healthy People
title_full	Determinants Of Plasma Homocysteine Levels In Healthy People
title_fullStr	Determinants Of Plasma Homocysteine Levels In Healthy People
title_full_unstemmed	Determinants Of Plasma Homocysteine Levels In Healthy People
title_sort	determinants of plasma homocysteine levels in healthy people
publisher	De Gruyter
publishDate	2006
url	https://doaj.org/article/43105e7f659f4ec39145ca897cbecba9
work_keys_str_mv	AT snuraksoy determinantsofplasmahomocysteinelevelsinhealthypeople AT iclalgeyikli determinantsofplasmahomocysteinelevelsinhealthypeople AT eilkersaygılı determinantsofplasmahomocysteinelevelsinhealthypeople
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Determinants Of Plasma Homocysteine Levels In Healthy People

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