Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism

Context: Cancer is the leading cause of death in the human population, ensuing from the accumulation of damage to genetic materials and affecting various parts of the organs. This review is focused on the cell signaling cross-talk mechanism of colorectal cancer (CRC) and its regulations. Genomic ins...

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Autores principales:	Muralidharan Jothimani, Lakshmanan Loganathan, Prahashini Palanisamy, Karthikeyan Muthusamy
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2020
Materias:	colorectal cancer cross-talking wnt/β-catenin ras topk p53 ubiquitin Medicine R
Acceso en línea:	https://doaj.org/article/43137dad3f9d4345bed3a08b9d4cca26
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spelling	oai:doaj.org-article:43137dad3f9d4345bed3a08b9d4cca262021-11-14T08:12:17ZRegulatory pathways of colorectal cancer and their synergistic cross-talk mechanism2783-243010.30476/acrr.2020.86258.1046https://doaj.org/article/43137dad3f9d4345bed3a08b9d4cca262020-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46977_6d3179be717ae8f45ee5df86d294e492.pdfhttps://doaj.org/toc/2783-2430Context: Cancer is the leading cause of death in the human population, ensuing from the accumulation of damage to genetic materials and affecting various parts of the organs. This review is focused on the cell signaling cross-talk mechanism of colorectal cancer (CRC) and its regulations. Genomic instability acts as the major driving force for CRC. The major CRC cascade mechanisms such as Wnt, Ras, TOPK, p53, and ubiquitin pathways were discussed. These interlinked signals cross-talk with one another in various regulatory mechanisms and play a unique role in CRC. Evidence Acquisition: The major cross-talking signals of CRC are the most significant part of this review. Wnt is a resource and center of axis for cross-talk and interlinked signaling mechanism. Wnt/β-catenin signaling was regulated by frizzled receptor, co-factors, Ras, TOPK, and many other mechanisms; related literature of CRC were collected through a literature survey and categorized using the keywords. The pathways with high specificity interlinked with Wnt were identified and used as the major targets for this review. Results and Conclusion: The interlinked signaling pathways and gene networks were explained with their specificity role in CRC. We highlighted the major regulatory signaling and interlinked pathways of CRC, as new multi targets approach. Furthermore, we discussed the potent targeted genes, bio-markers for a better prognosis, and therapies for CRC patients. Through highlighting the gene cross-talking signaling cascade; we have provided the source for gene network interaction and targeted therapy. This study paves the way for multi-targeting of interlinked pathways and suggesting these would be perfect for suppressing of CRC. The signaling pathways discussed in this review are not only focused on CRC but also the new potent targets and bio-markers for different types of cancers. Targeting multiple interlinked pathways could be useful for developing new potential bio-markers for treatment and diagnosis purposes.Muralidharan JothimaniLakshmanan LoganathanPrahashini PalanisamyKarthikeyan MuthusamyShiraz University of Medical Sciencesarticlecolorectal cancercross-talkingwnt/β-cateninrastopkp53ubiquitinMedicineRENIranian Journal of Colorectal Research, Vol 8, Iss 3, Pp 105-119 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer cross-talking wnt/β-catenin ras topk p53 ubiquitin Medicine R
spellingShingle	colorectal cancer cross-talking wnt/β-catenin ras topk p53 ubiquitin Medicine R Muralidharan Jothimani Lakshmanan Loganathan Prahashini Palanisamy Karthikeyan Muthusamy Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
description	Context: Cancer is the leading cause of death in the human population, ensuing from the accumulation of damage to genetic materials and affecting various parts of the organs. This review is focused on the cell signaling cross-talk mechanism of colorectal cancer (CRC) and its regulations. Genomic instability acts as the major driving force for CRC. The major CRC cascade mechanisms such as Wnt, Ras, TOPK, p53, and ubiquitin pathways were discussed. These interlinked signals cross-talk with one another in various regulatory mechanisms and play a unique role in CRC. Evidence Acquisition: The major cross-talking signals of CRC are the most significant part of this review. Wnt is a resource and center of axis for cross-talk and interlinked signaling mechanism. Wnt/β-catenin signaling was regulated by frizzled receptor, co-factors, Ras, TOPK, and many other mechanisms; related literature of CRC were collected through a literature survey and categorized using the keywords. The pathways with high specificity interlinked with Wnt were identified and used as the major targets for this review. Results and Conclusion: The interlinked signaling pathways and gene networks were explained with their specificity role in CRC. We highlighted the major regulatory signaling and interlinked pathways of CRC, as new multi targets approach. Furthermore, we discussed the potent targeted genes, bio-markers for a better prognosis, and therapies for CRC patients. Through highlighting the gene cross-talking signaling cascade; we have provided the source for gene network interaction and targeted therapy. This study paves the way for multi-targeting of interlinked pathways and suggesting these would be perfect for suppressing of CRC. The signaling pathways discussed in this review are not only focused on CRC but also the new potent targets and bio-markers for different types of cancers. Targeting multiple interlinked pathways could be useful for developing new potential bio-markers for treatment and diagnosis purposes.
format	article
author	Muralidharan Jothimani Lakshmanan Loganathan Prahashini Palanisamy Karthikeyan Muthusamy
author_facet	Muralidharan Jothimani Lakshmanan Loganathan Prahashini Palanisamy Karthikeyan Muthusamy
author_sort	Muralidharan Jothimani
title	Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
title_short	Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
title_full	Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
title_fullStr	Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
title_full_unstemmed	Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
title_sort	regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism
publisher	Shiraz University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/43137dad3f9d4345bed3a08b9d4cca26
work_keys_str_mv	AT muralidharanjothimani regulatorypathwaysofcolorectalcancerandtheirsynergisticcrosstalkmechanism AT lakshmananloganathan regulatorypathwaysofcolorectalcancerandtheirsynergisticcrosstalkmechanism AT prahashinipalanisamy regulatorypathwaysofcolorectalcancerandtheirsynergisticcrosstalkmechanism AT karthikeyanmuthusamy regulatorypathwaysofcolorectalcancerandtheirsynergisticcrosstalkmechanism
_version_	1718429773543243776

Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism

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