Engineering and application of a biosensor with focused ligand specificity

Transcriptional biosensors represent powerful tools for the screening of vast strain libraries, but the broad ligand specificity of some transcriptional regulators (TRs) can prohibit such applications. Here authors present the engineering of a LysG-based biosensor with a focused ligand specificity t...

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Autores principales:	Dennis Della Corte, Hugo L. van Beek, Falk Syberg, Marcus Schallmey, Felix Tobola, Kai U. Cormann, Christine Schlicker, Philipp T. Baumann, Karin Krumbach, Sascha Sokolowsky, Connor J. Morris, Alexander Grünberger, Eckhard Hofmann, Gunnar F. Schröder, Jan Marienhagen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43140052d6614d1abc93af4f2bc79843
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spelling	oai:doaj.org-article:43140052d6614d1abc93af4f2bc798432021-12-02T18:14:16ZEngineering and application of a biosensor with focused ligand specificity10.1038/s41467-020-18400-02041-1723https://doaj.org/article/43140052d6614d1abc93af4f2bc798432020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18400-0https://doaj.org/toc/2041-1723Transcriptional biosensors represent powerful tools for the screening of vast strain libraries, but the broad ligand specificity of some transcriptional regulators (TRs) can prohibit such applications. Here authors present the engineering of a LysG-based biosensor with a focused ligand specificity to isolate L-histidine-producing strains.Dennis Della CorteHugo L. van BeekFalk SybergMarcus SchallmeyFelix TobolaKai U. CormannChristine SchlickerPhilipp T. BaumannKarin KrumbachSascha SokolowskyConnor J. MorrisAlexander GrünbergerEckhard HofmannGunnar F. SchröderJan MarienhagenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis Della Corte Hugo L. van Beek Falk Syberg Marcus Schallmey Felix Tobola Kai U. Cormann Christine Schlicker Philipp T. Baumann Karin Krumbach Sascha Sokolowsky Connor J. Morris Alexander Grünberger Eckhard Hofmann Gunnar F. Schröder Jan Marienhagen Engineering and application of a biosensor with focused ligand specificity
description	Transcriptional biosensors represent powerful tools for the screening of vast strain libraries, but the broad ligand specificity of some transcriptional regulators (TRs) can prohibit such applications. Here authors present the engineering of a LysG-based biosensor with a focused ligand specificity to isolate L-histidine-producing strains.
format	article
author	Dennis Della Corte Hugo L. van Beek Falk Syberg Marcus Schallmey Felix Tobola Kai U. Cormann Christine Schlicker Philipp T. Baumann Karin Krumbach Sascha Sokolowsky Connor J. Morris Alexander Grünberger Eckhard Hofmann Gunnar F. Schröder Jan Marienhagen
author_facet	Dennis Della Corte Hugo L. van Beek Falk Syberg Marcus Schallmey Felix Tobola Kai U. Cormann Christine Schlicker Philipp T. Baumann Karin Krumbach Sascha Sokolowsky Connor J. Morris Alexander Grünberger Eckhard Hofmann Gunnar F. Schröder Jan Marienhagen
author_sort	Dennis Della Corte
title	Engineering and application of a biosensor with focused ligand specificity
title_short	Engineering and application of a biosensor with focused ligand specificity
title_full	Engineering and application of a biosensor with focused ligand specificity
title_fullStr	Engineering and application of a biosensor with focused ligand specificity
title_full_unstemmed	Engineering and application of a biosensor with focused ligand specificity
title_sort	engineering and application of a biosensor with focused ligand specificity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/43140052d6614d1abc93af4f2bc79843
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Engineering and application of a biosensor with focused ligand specificity

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