Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration

The population-based approach has been widely applied to describe the pharmacokinetic profile of many drugs. The aim of this current research was to study the implementation of the population-based pharmacokinetics of levofloxacin in rabbits administered by intravenous bolus injection and peroral de...

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Autores principales:	Akhmad Kharis Nugroho, Puspa Dwi Pratiwi, Shesanti Citrariana, Endang Lukitaningsih, Lukman Hakim
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	monolix, intravenous bolus, peroral, the goodness of fit Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4314f6eeccc4400faa079c4bd8cd9b43
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spelling	oai:doaj.org-article:4314f6eeccc4400faa079c4bd8cd9b432021-11-15T06:08:46ZPopulation Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration2338-94272338-948610.22146/ijp.1073https://doaj.org/article/4314f6eeccc4400faa079c4bd8cd9b432021-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1073https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486The population-based approach has been widely applied to describe the pharmacokinetic profile of many drugs. The aim of this current research was to study the implementation of the population-based pharmacokinetics of levofloxacin in rabbits administered by intravenous bolus injection and peroral delivery. Modeling analyses were performed using Monolix, one of the alternative tools for the population-based approach. Monolix works based on the Stochastic Approximation Expectation-Maximization (SAEM) method. The analysis was performed based on the population model using one-compartmental and two-compartmental disposition models. The combination error model was used during the analyses. Modeling appropriateness was determined based on the goodness of fit analyses, i.e., 1) the individual fit, 2) the observed versus population prediction values; and 3) the observed versus individual prediction values Plasma concentration profiles of levofloxacin by intravenous bolus injection and oral administration are better described by an appropriate model using a two-compartmental disposition model. All goodness of fit analyses demonstrates the power of the chosen model. However, the estimated disposition parameter values obtained based on the intravenous bolus injection and peroral administration are different for each subject. To confirm this phenomenon, we performed a simultaneous fitting of all intravenous bolus as well as peroral administration data. The goodness of fit analyses indicates an adequate fitting of all data.Akhmad Kharis NugrohoPuspa Dwi PratiwiShesanti CitrarianaEndang LukitaningsihLukman HakimUniversitas Gadjah Madaarticlemonolix, intravenous bolus, peroral, the goodness of fitPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 349–355-349–355 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	monolix, intravenous bolus, peroral, the goodness of fit Pharmacy and materia medica RS1-441
spellingShingle	monolix, intravenous bolus, peroral, the goodness of fit Pharmacy and materia medica RS1-441 Akhmad Kharis Nugroho Puspa Dwi Pratiwi Shesanti Citrariana Endang Lukitaningsih Lukman Hakim Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
description	The population-based approach has been widely applied to describe the pharmacokinetic profile of many drugs. The aim of this current research was to study the implementation of the population-based pharmacokinetics of levofloxacin in rabbits administered by intravenous bolus injection and peroral delivery. Modeling analyses were performed using Monolix, one of the alternative tools for the population-based approach. Monolix works based on the Stochastic Approximation Expectation-Maximization (SAEM) method. The analysis was performed based on the population model using one-compartmental and two-compartmental disposition models. The combination error model was used during the analyses. Modeling appropriateness was determined based on the goodness of fit analyses, i.e., 1) the individual fit, 2) the observed versus population prediction values; and 3) the observed versus individual prediction values Plasma concentration profiles of levofloxacin by intravenous bolus injection and oral administration are better described by an appropriate model using a two-compartmental disposition model. All goodness of fit analyses demonstrates the power of the chosen model. However, the estimated disposition parameter values obtained based on the intravenous bolus injection and peroral administration are different for each subject. To confirm this phenomenon, we performed a simultaneous fitting of all intravenous bolus as well as peroral administration data. The goodness of fit analyses indicates an adequate fitting of all data.
format	article
author	Akhmad Kharis Nugroho Puspa Dwi Pratiwi Shesanti Citrariana Endang Lukitaningsih Lukman Hakim
author_facet	Akhmad Kharis Nugroho Puspa Dwi Pratiwi Shesanti Citrariana Endang Lukitaningsih Lukman Hakim
author_sort	Akhmad Kharis Nugroho
title	Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
title_short	Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
title_full	Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
title_fullStr	Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
title_full_unstemmed	Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
title_sort	population pharmacokinetics modeling of levofloxacin in rabbit by intravenous bolus injection and peroral administration
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/4314f6eeccc4400faa079c4bd8cd9b43
work_keys_str_mv	AT akhmadkharisnugroho populationpharmacokineticsmodelingoflevofloxacininrabbitbyintravenousbolusinjectionandperoraladministration AT puspadwipratiwi populationpharmacokineticsmodelingoflevofloxacininrabbitbyintravenousbolusinjectionandperoraladministration AT shesanticitrariana populationpharmacokineticsmodelingoflevofloxacininrabbitbyintravenousbolusinjectionandperoraladministration AT endanglukitaningsih populationpharmacokineticsmodelingoflevofloxacininrabbitbyintravenousbolusinjectionandperoraladministration AT lukmanhakim populationpharmacokineticsmodelingoflevofloxacininrabbitbyintravenousbolusinjectionandperoraladministration
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Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration

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