The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

Abstract N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits. Crystal structures of αIIbβ3 and αVβ3 have resolved the precise structural location of each N-glyc...

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Autores principales: Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/431d93d9f57341798f20c2a6e6140743
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