Possible association between subtypes of dry eye disease and seasonal variation

Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi Department of Ophthalmology, Keio University, Shinjuku, Tokyo, Japan Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross...

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Autores principales:	Ayaki M, Kawashima M, Uchino M, Tsubota K, Negishi K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	dry eye disease seasonality tear break-up time Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/431df7e0b462484a99bd9ab4251ec6ee
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spelling	oai:doaj.org-article:431df7e0b462484a99bd9ab4251ec6ee2021-12-02T00:46:23ZPossible association between subtypes of dry eye disease and seasonal variation1177-5483https://doaj.org/article/431df7e0b462484a99bd9ab4251ec6ee2017-09-01T00:00:00Zhttps://www.dovepress.com/possible-association-between-subtypes-of-dry-eye-disease-and-seasonal--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi Department of Ophthalmology, Keio University, Shinjuku, Tokyo, Japan Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest. Keywords: dry eye disease, seasonality, tear break-up time, cornea, ocular surface, tear production, hay fever, air pollen, allergic conjunctivitisAyaki MKawashima MUchino MTsubota KNegishi KDove Medical Pressarticledry eye diseaseseasonalitytear break-up timeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1769-1775 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye disease seasonality tear break-up time Ophthalmology RE1-994
spellingShingle	dry eye disease seasonality tear break-up time Ophthalmology RE1-994 Ayaki M Kawashima M Uchino M Tsubota K Negishi K Possible association between subtypes of dry eye disease and seasonal variation
description	Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi Department of Ophthalmology, Keio University, Shinjuku, Tokyo, Japan Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest. Keywords: dry eye disease, seasonality, tear break-up time, cornea, ocular surface, tear production, hay fever, air pollen, allergic conjunctivitis
format	article
author	Ayaki M Kawashima M Uchino M Tsubota K Negishi K
author_facet	Ayaki M Kawashima M Uchino M Tsubota K Negishi K
author_sort	Ayaki M
title	Possible association between subtypes of dry eye disease and seasonal variation
title_short	Possible association between subtypes of dry eye disease and seasonal variation
title_full	Possible association between subtypes of dry eye disease and seasonal variation
title_fullStr	Possible association between subtypes of dry eye disease and seasonal variation
title_full_unstemmed	Possible association between subtypes of dry eye disease and seasonal variation
title_sort	possible association between subtypes of dry eye disease and seasonal variation
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/431df7e0b462484a99bd9ab4251ec6ee
work_keys_str_mv	AT ayakim possibleassociationbetweensubtypesofdryeyediseaseandseasonalvariation AT kawashimam possibleassociationbetweensubtypesofdryeyediseaseandseasonalvariation AT uchinom possibleassociationbetweensubtypesofdryeyediseaseandseasonalvariation AT tsubotak possibleassociationbetweensubtypesofdryeyediseaseandseasonalvariation AT negishik possibleassociationbetweensubtypesofdryeyediseaseandseasonalvariation
_version_	1718403489833418752

Possible association between subtypes of dry eye disease and seasonal variation

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