Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation

Abstract It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 controls). Time Line Follow-Back questionnaire was used...

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Autores principales:	Suthat Liangpunsakul, Evelyn Toh, Ruth A. Ross, Laura E. Heathers, Kristina Chandler, AdePeju Oshodi, Breann McGee, Elizabeth Modlik, Tobyn Linton, Darrin Mangiacarne, Claudie Jimenez, X. Charlie Dong, Li Wang, Wanzhu Tu, David E. Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43223bad8bfa489eae116c4d4e66b2c2
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spelling	oai:doaj.org-article:43223bad8bfa489eae116c4d4e66b2c22021-12-02T15:05:29ZQuantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation10.1038/s41598-017-04669-72045-2322https://doaj.org/article/43223bad8bfa489eae116c4d4e66b2c22017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04669-7https://doaj.org/toc/2045-2322Abstract It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 controls). Time Line Follow-Back questionnaire was used to quantify the amount of alcohol consumed. Serum LPS, sCD14, and sCD163 were measured. Peripheral blood mononuclear cells (PBMCs) were also isolated. Compared to controls, ED had higher total drinks in the past 30 days, higher levels of LPS, sCD14 and sCD163. The levels of serum LPS, sCD14, and sCD163 were higher among ED with recent alcohol consumption (last drink <10 days before enrollment) compared to those without recent drinking. Similar bacterial genome copy numbers were detected in control and ED groups. We found that ethanol primed PBMCs for LPS-induced inflammatory responses. A positive correlation between serum LPS, sCD14, sCD163 and the quantity of alcohol drinking was observed after adjusting for covariates and that abstinence was associated with decline in the levels of LPS, sCD14 and sCd163. We found an increase in the levels of LPS and markers of monocyte activations in ED. Further studies are needed to determine whether these can be used as the biomarkers for excessive alcohol use.Suthat LiangpunsakulEvelyn TohRuth A. RossLaura E. HeathersKristina ChandlerAdePeju OshodiBreann McGeeElizabeth ModlikTobyn LintonDarrin MangiacarneClaudie JimenezX. Charlie DongLi WangWanzhu TuDavid E. NelsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suthat Liangpunsakul Evelyn Toh Ruth A. Ross Laura E. Heathers Kristina Chandler AdePeju Oshodi Breann McGee Elizabeth Modlik Tobyn Linton Darrin Mangiacarne Claudie Jimenez X. Charlie Dong Li Wang Wanzhu Tu David E. Nelson Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
description	Abstract It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 controls). Time Line Follow-Back questionnaire was used to quantify the amount of alcohol consumed. Serum LPS, sCD14, and sCD163 were measured. Peripheral blood mononuclear cells (PBMCs) were also isolated. Compared to controls, ED had higher total drinks in the past 30 days, higher levels of LPS, sCD14 and sCD163. The levels of serum LPS, sCD14, and sCD163 were higher among ED with recent alcohol consumption (last drink <10 days before enrollment) compared to those without recent drinking. Similar bacterial genome copy numbers were detected in control and ED groups. We found that ethanol primed PBMCs for LPS-induced inflammatory responses. A positive correlation between serum LPS, sCD14, sCD163 and the quantity of alcohol drinking was observed after adjusting for covariates and that abstinence was associated with decline in the levels of LPS, sCD14 and sCd163. We found an increase in the levels of LPS and markers of monocyte activations in ED. Further studies are needed to determine whether these can be used as the biomarkers for excessive alcohol use.
format	article
author	Suthat Liangpunsakul Evelyn Toh Ruth A. Ross Laura E. Heathers Kristina Chandler AdePeju Oshodi Breann McGee Elizabeth Modlik Tobyn Linton Darrin Mangiacarne Claudie Jimenez X. Charlie Dong Li Wang Wanzhu Tu David E. Nelson
author_facet	Suthat Liangpunsakul Evelyn Toh Ruth A. Ross Laura E. Heathers Kristina Chandler AdePeju Oshodi Breann McGee Elizabeth Modlik Tobyn Linton Darrin Mangiacarne Claudie Jimenez X. Charlie Dong Li Wang Wanzhu Tu David E. Nelson
author_sort	Suthat Liangpunsakul
title	Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
title_short	Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
title_full	Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
title_fullStr	Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
title_full_unstemmed	Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
title_sort	quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43223bad8bfa489eae116c4d4e66b2c2
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Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation

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