The curious case of benzbromarone: insight into super-inhibition of cytochrome P450.

The curious case of benzbromarone: insight into super-inhibition of cytochrome P450.

Cytochrome P450 (CYP) family of redox enzymes metabolize drugs and xenobiotics in liver microsomes. Isozyme CYP2C9 is reported to be inhibited by benzbromarone (BzBr) and this phenomenon was hitherto explained by classical active-site binding. Theoretically, it was impossible to envisage the experim...

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Autores principales: Abhinav Parashar, Sudeep Kumar Gade, Mahesh Potnuru, Nandita Madhavan, Kelath Murali Manoj
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/432548fa0e99427e94d0f25f342a6224
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