Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model

Jirakrit Leelarungrayub,1 Jiradej Manorsoi,2,3 Aranya Manorsoi2,3 1Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, 2Manose Health and Beauty Research Center, Mueng, 3Division of Cosmetic Technology, Faculty of Science and Technology, North Chiang Mai U...

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Autores principales:	Leelarungrayub J, Manorsoi J, Manorsoi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Anti-oxidant Anti-inflammation Plai oil Niosomes Ultrasound Zingiber cassumnar Roxb. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/43298f105a774e9abf585a716da93f31
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spelling	oai:doaj.org-article:43298f105a774e9abf585a716da93f312021-12-02T04:33:06ZAnti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model1178-2013https://doaj.org/article/43298f105a774e9abf585a716da93f312017-03-01T00:00:00Zhttps://www.dovepress.com/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingibe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jirakrit Leelarungrayub,1 Jiradej Manorsoi,2,3 Aranya Manorsoi2,3 1Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, 2Manose Health and Beauty Research Center, Mueng, 3Division of Cosmetic Technology, Faculty of Science and Technology, North Chiang Mai University, Chiang Mai, Thailand Objective: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil–encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. Methods: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry. Niosome particles containing Plai oil were prepared by chloroform film method with sonication before testing for anti-inflammatory activity on locally inflamed subcutaneous rat skin after inducement from lipopolysaccharide with ultrasound once a day for 3 days. Skin temperatures and blood flow were evaluated. Results: Plai oil presented antioxidant activity that inhibited 2,2-diphenyl-1-picrylhydrazyl radicals. Four active compounds found in the essential oil were sabinene, γ-terpinene, terpinene-4-ol, and (E)-1-(3,4-dimethyoxy phenyl) butadiene. Application of ultrasound (0.2 W/cm2, 20%, 3 min) with gel containing Plai oil–encapsulated niosomes decreased skin temperature and blood flow to the lowest level compared to the application of neurofen drug or gel-based control. Conclusion: Plai oil, which consists of four main bioactive compounds and possesses antioxidant and anti-inflammatory activities, can be applied against local subcutaneous inflammation when used with therapeutic ultrasound via entrapped niosomes. Keywords: antioxidant, anti-inflammation, Plai oil, niosomes, therapeutic ultrasound, Zingiber cassumunar Roxb.Leelarungrayub JManorsoi JManorsoi ADove Medical PressarticleAnti-oxidantAnti-inflammationPlai oilNiosomesUltrasoundZingiber cassumnar Roxb.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2469-2476 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anti-oxidant Anti-inflammation Plai oil Niosomes Ultrasound Zingiber cassumnar Roxb. Medicine (General) R5-920
spellingShingle	Anti-oxidant Anti-inflammation Plai oil Niosomes Ultrasound Zingiber cassumnar Roxb. Medicine (General) R5-920 Leelarungrayub J Manorsoi J Manorsoi A Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
description	Jirakrit Leelarungrayub,1 Jiradej Manorsoi,2,3 Aranya Manorsoi2,3 1Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, 2Manose Health and Beauty Research Center, Mueng, 3Division of Cosmetic Technology, Faculty of Science and Technology, North Chiang Mai University, Chiang Mai, Thailand Objective: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil–encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. Methods: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry. Niosome particles containing Plai oil were prepared by chloroform film method with sonication before testing for anti-inflammatory activity on locally inflamed subcutaneous rat skin after inducement from lipopolysaccharide with ultrasound once a day for 3 days. Skin temperatures and blood flow were evaluated. Results: Plai oil presented antioxidant activity that inhibited 2,2-diphenyl-1-picrylhydrazyl radicals. Four active compounds found in the essential oil were sabinene, γ-terpinene, terpinene-4-ol, and (E)-1-(3,4-dimethyoxy phenyl) butadiene. Application of ultrasound (0.2 W/cm2, 20%, 3 min) with gel containing Plai oil–encapsulated niosomes decreased skin temperature and blood flow to the lowest level compared to the application of neurofen drug or gel-based control. Conclusion: Plai oil, which consists of four main bioactive compounds and possesses antioxidant and anti-inflammatory activities, can be applied against local subcutaneous inflammation when used with therapeutic ultrasound via entrapped niosomes. Keywords: antioxidant, anti-inflammation, Plai oil, niosomes, therapeutic ultrasound, Zingiber cassumunar Roxb.
format	article
author	Leelarungrayub J Manorsoi J Manorsoi A
author_facet	Leelarungrayub J Manorsoi J Manorsoi A
author_sort	Leelarungrayub J
title	Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
title_short	Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
title_full	Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
title_fullStr	Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
title_full_unstemmed	Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model
title_sort	anti-inflammatory activity of niosomes entrapped with plai oil (zingiber cassumunar roxb.) by therapeutic ultrasound in a rat model
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/43298f105a774e9abf585a716da93f31
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_version_	1718401179355971584

Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model

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