Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort

Abstract Allergic diseases are the most common chronic diseases in childrenin the Western world, but little is know about what factors influence immune maturation and allergy development. We therefore aimed to associate infant and maternal metabolomes to T- and B-cell subpopulations and allergy diag...

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Autores principales: Olle Hartvigsson, Malin Barman, Hardis Rabe, Anna Sandin, Agnes E. Wold, Carl Brunius, Ann-Sofie Sandberg
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:432b96d8d183488eacfbd4c33d806be52021-12-02T17:13:27ZAssociations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort10.1038/s41598-021-92239-32045-2322https://doaj.org/article/432b96d8d183488eacfbd4c33d806be52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92239-3https://doaj.org/toc/2045-2322Abstract Allergic diseases are the most common chronic diseases in childrenin the Western world, but little is know about what factors influence immune maturation and allergy development. We therefore aimed to associate infant and maternal metabolomes to T- and B-cell subpopulations and allergy diagnosis. We performed liquid chromatography-mass spectrometry based untargeted metabolomics on blood plasma from mothers (third trimester, n = 605; delivery, n = 558) and from the umbilical cord (n = 366). The measured metabolomes were associated to T- and B-cell subpopulations up to 4 months after delivery and to doctor´s diagnosed eczema, food allergy and asthma at one year of age using random forest analysis. Maternal and cord plasma at delivery could predict the number of CD24+CD38low memory B-cells (p = 0.033, n = 26 and p = 0.009, n = 22), but future allergy status could not be distinguished from any of the three measured metabolomes. Replication of previous literature findings showed hypoxanthine to be upregulated in the umbilical cord of children with subsequent asthma. This exploratory study suggests foetal immune programming occuring during pregnancy as the metabolomic profiles of mothers and infants at delivery related to infants’ B-cell maturation.Olle HartvigssonMalin BarmanHardis RabeAnna SandinAgnes E. WoldCarl BruniusAnn-Sofie SandbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Olle Hartvigsson
Malin Barman
Hardis Rabe
Anna Sandin
Agnes E. Wold
Carl Brunius
Ann-Sofie Sandberg
Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
description Abstract Allergic diseases are the most common chronic diseases in childrenin the Western world, but little is know about what factors influence immune maturation and allergy development. We therefore aimed to associate infant and maternal metabolomes to T- and B-cell subpopulations and allergy diagnosis. We performed liquid chromatography-mass spectrometry based untargeted metabolomics on blood plasma from mothers (third trimester, n = 605; delivery, n = 558) and from the umbilical cord (n = 366). The measured metabolomes were associated to T- and B-cell subpopulations up to 4 months after delivery and to doctor´s diagnosed eczema, food allergy and asthma at one year of age using random forest analysis. Maternal and cord plasma at delivery could predict the number of CD24+CD38low memory B-cells (p = 0.033, n = 26 and p = 0.009, n = 22), but future allergy status could not be distinguished from any of the three measured metabolomes. Replication of previous literature findings showed hypoxanthine to be upregulated in the umbilical cord of children with subsequent asthma. This exploratory study suggests foetal immune programming occuring during pregnancy as the metabolomic profiles of mothers and infants at delivery related to infants’ B-cell maturation.
format article
author Olle Hartvigsson
Malin Barman
Hardis Rabe
Anna Sandin
Agnes E. Wold
Carl Brunius
Ann-Sofie Sandberg
author_facet Olle Hartvigsson
Malin Barman
Hardis Rabe
Anna Sandin
Agnes E. Wold
Carl Brunius
Ann-Sofie Sandberg
author_sort Olle Hartvigsson
title Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
title_short Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
title_full Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
title_fullStr Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
title_full_unstemmed Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
title_sort associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the swedish nice-cohort
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/432b96d8d183488eacfbd4c33d806be5
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