Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis

Abstract To evaluate the relationship between wall shear stress (WSS) magnitude and cerebral aneurysm rupture and provide new insight into the disparate computational fluid dynamics (CFD) findings concerning the role of WSS in intracranial aneurysm (IA) rupture. A systematic electronic database (Pub...

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Autores principales:	Geng Zhou, Yueqi Zhu, Yanling Yin, Ming Su, Minghua Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/432c788139e9403a8f3027447af395ab
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spelling	oai:doaj.org-article:432c788139e9403a8f3027447af395ab2021-12-02T16:06:10ZAssociation of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis10.1038/s41598-017-05886-w2045-2322https://doaj.org/article/432c788139e9403a8f3027447af395ab2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05886-whttps://doaj.org/toc/2045-2322Abstract To evaluate the relationship between wall shear stress (WSS) magnitude and cerebral aneurysm rupture and provide new insight into the disparate computational fluid dynamics (CFD) findings concerning the role of WSS in intracranial aneurysm (IA) rupture. A systematic electronic database (PubMed, Medline, Springer, and EBSCO) search was conducted for all accessible published articles up to July 1, 2016, with no restriction on the publication year. Abstracts, full-text manuscripts, and the reference lists of retrieved articles were analyzed. Random effects meta-analysis was used to pool the complication rates across studies. Twenty-two studies containing CFD data on 1257 patients with aneurysms were included in the analysis. A significantly higher rate of low WSS (0–1.5 Pa) was found in ruptured aneurysms (odds ratio [OR] 2.17; 95% confidence interval [CI], 1.73–2.62). The pooled analyses across 14 studies with low WSS showed significantly lower mean WSS (0.64 vs. 1.4 Pa) (p = 0.037) in the ruptured group. This meta-analysis provides evidence that decreased local WSS may be an important predictive parameter of IA rupture.Geng ZhouYueqi ZhuYanling YinMing SuMinghua LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geng Zhou Yueqi Zhu Yanling Yin Ming Su Minghua Li Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
description	Abstract To evaluate the relationship between wall shear stress (WSS) magnitude and cerebral aneurysm rupture and provide new insight into the disparate computational fluid dynamics (CFD) findings concerning the role of WSS in intracranial aneurysm (IA) rupture. A systematic electronic database (PubMed, Medline, Springer, and EBSCO) search was conducted for all accessible published articles up to July 1, 2016, with no restriction on the publication year. Abstracts, full-text manuscripts, and the reference lists of retrieved articles were analyzed. Random effects meta-analysis was used to pool the complication rates across studies. Twenty-two studies containing CFD data on 1257 patients with aneurysms were included in the analysis. A significantly higher rate of low WSS (0–1.5 Pa) was found in ruptured aneurysms (odds ratio [OR] 2.17; 95% confidence interval [CI], 1.73–2.62). The pooled analyses across 14 studies with low WSS showed significantly lower mean WSS (0.64 vs. 1.4 Pa) (p = 0.037) in the ruptured group. This meta-analysis provides evidence that decreased local WSS may be an important predictive parameter of IA rupture.
format	article
author	Geng Zhou Yueqi Zhu Yanling Yin Ming Su Minghua Li
author_facet	Geng Zhou Yueqi Zhu Yanling Yin Ming Su Minghua Li
author_sort	Geng Zhou
title	Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
title_short	Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
title_full	Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
title_fullStr	Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
title_full_unstemmed	Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
title_sort	association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/432c788139e9403a8f3027447af395ab
work_keys_str_mv	AT gengzhou associationofwallshearstresswithintracranialaneurysmrupturesystematicreviewandmetaanalysis AT yueqizhu associationofwallshearstresswithintracranialaneurysmrupturesystematicreviewandmetaanalysis AT yanlingyin associationofwallshearstresswithintracranialaneurysmrupturesystematicreviewandmetaanalysis AT mingsu associationofwallshearstresswithintracranialaneurysmrupturesystematicreviewandmetaanalysis AT minghuali associationofwallshearstresswithintracranialaneurysmrupturesystematicreviewandmetaanalysis
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Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis

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